Inhibitors of nucleic acid synthesis

  • T. J. Franklin
  • G. A. Snow


Many antimicrobial substances, both synthetic chemicals and natural products, inhibit the biosynthesis of nucleic acids. However, few of these inhibitors are clinically useful as antimicrobial drugs because most do not distinguish between nucleic acid synthesis in the infecting micro-organism and in the host. Many inhibitors of nucleic acid synthesis are therefore too toxic to the host for safe use as antimicrobial agents. However, there are important exceptions which are described in this chapter.


Thymidine Kinase Nucleoside Analogue Double Helix Dihydrofolate Reductase Nucleic Acid Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Further reading

  1. Gootz, T. D. and Brighty, K. E. (1996). Fluoroquinolone antibacterials: SAR, mechanism of action, resistance and clinical aspects. Medicin. Res. Rev. 16, 433.CrossRefGoogle Scholar
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Copyright information

© The Kluwer Academic Publishers 1998

Authors and Affiliations

  • T. J. Franklin
    • 1
  • G. A. Snow
    • 1
  1. 1.Zeneca PharmaceuticalsAlderley Park, Macclesfield, CheshireUK

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