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Excitation and Ionization of 5-Halouracils: ESR and ENDOR of Single Crystals

  • Jürgen Hüttermann
Conference paper
Part of the The Jerusalem Symposia on Quantum Chemistry and Biochemistry book series (JSQC, volume 10)

Abstract

The response of 5-halogen substituted analogs of the nucleic acid base uracil to excitation by UV-light or ionizing radiation is a topic of interest in radiation biology since nearly two decades. These components and their nucleoside(-tide) derivatives, (I), can be incorporated into DNA of actively proliferating cells in place of the corresponding thymine residues. Irradiation of cells containing the halogenated analogs produces an up to four-fold increase in lethal, biological damage.

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Copyright information

© Springer Science+Business Media Dordrecht 1977

Authors and Affiliations

  • Jürgen Hüttermann
    • 1
  1. 1.Institut für Biophysik und physikalische BiochemieUniversitätRegensburgGermany

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