Excitation and Ionization of 5-Halouracils: ESR and ENDOR of Single Crystals

  • Jürgen Hüttermann
Conference paper
Part of the The Jerusalem Symposia on Quantum Chemistry and Biochemistry book series (JSQC, volume 10)


The response of 5-halogen substituted analogs of the nucleic acid base uracil to excitation by UV-light or ionizing radiation is a topic of interest in radiation biology since nearly two decades. These components and their nucleoside(-tide) derivatives, (I), can be incorporated into DNA of actively proliferating cells in place of the corresponding thymine residues. Irradiation of cells containing the halogenated analogs produces an up to four-fold increase in lethal, biological damage.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. (1).
    F. Hutchinson, Quart.Rev.Biophys. 6, 201 (1973).CrossRefGoogle Scholar
  2. (2).
    W. Szybalski, Cancer Chemotherapy Reports Part 1, 58, 539 (1974).Google Scholar
  3. (3).
    P. Neta, J.Phys.Chem. 76, 2399 (1972).CrossRefGoogle Scholar
  4. (4).
    J.D. Zimbrick, J.F.B Ward, and L.S. Myers, Jr., Int.J.Radiat.Biol. 16, 505 (1969).CrossRefGoogle Scholar
  5. (5).
    Program MAGNSPEC3. QCPE 150 (Indiana University, Chemistry Dept.).Google Scholar
  6. (6).
    J. Hüttermann and A. Müller, Int.J.Radiat.Biol. 4, 297 (1969).CrossRefGoogle Scholar
  7. (7).
    W. Neumüller, Thesis (University of Regensburg), (1976).Google Scholar
  8. (8).
    H. Oloff and J. Hüttermann, J.Magn.Res., in press (1977).Google Scholar
  9. (9).
    R.A. Farley and W.A. Bernhard, Radiat.Res. 61, 47 (1975).CrossRefGoogle Scholar
  10. (10).
    W.A. Bernhard, D.M. Close, J. Hüttermann, and H. Zehner, J.Chem.Phys., in press (1977).Google Scholar
  11. (11).
    H.C. Box and E.E. Budzinski, J.Chem.Phys. 62, 197 (1975).CrossRefGoogle Scholar
  12. (12).
    R. Bergene and R.A. Vaughan, Int.J.Radiat.Biol. 29 14–5 (1976).Google Scholar
  13. (13).
    J. Hüttermann, W.A. Bernhard, E. Haindl, and G. Schmidt, Int.J.Radiat.Biol., submitted for publication.Google Scholar
  14. (14).
    J. Hüttermann, W.A. Bernhard, E. Haindl, and G. Schmidt, J.Phys.Chem., in press (1977).Google Scholar
  15. (15).
    J. Hüttermann, W.A. Bernhard, E. Haindl, and G. Schmidt, Mol.Phys. 32, 1111 (1976).CrossRefGoogle Scholar
  16. (16).
    E. Haindl and J. Hüttermann, J.Magn.Res., submitted for publication.Google Scholar
  17. (17).
    J. Huttermann, G.W. Neilson, and M.C.R. Symons, Mol.Phys. 32, 269 (1976).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1977

Authors and Affiliations

  • Jürgen Hüttermann
    • 1
  1. 1.Institut für Biophysik und physikalische BiochemieUniversitätRegensburgGermany

Personalised recommendations