Advertisement

Specificity of Photochemical Cross-Linking in Protein-Nucleic Acid Complexes

  • Joseph Sperling
  • Abraham Havron
Conference paper
Part of the The Jerusalem Symposia on Quantum Chemistry and Biochemistry book series (JSQC, volume 10)

Abstract

The active study of protein-nucleic acid interactions in recent years, has emphasized the critical role these interactions play in life processes and their control. The high affinities observed in protein-nucleic acid complexes, can be accounted for by assuming the occurrence of simultaneous interactions of a number of functional groups on the two partners. However, the molecular mechanism upon which these specific interactions are based is not yet understood in detail.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Elad, D., in Aging, Carcinogenesis, and Radiation Biology, Smith, K.C., Ed., New York, Plenum Press, p 243.Google Scholar
  2. Elad, D., Rosenthal, I., and Sasson, S. (1971), J. Chem. Soc. (C), 2053.Google Scholar
  3. Fisher, G.J., Varghese, A.J., and Johns, H.E. (1974), Photochem. Photobiol., 20, 109.Google Scholar
  4. Matsubara, H. (1970), Methods Enzymol., 19, 648.Google Scholar
  5. Richards, F.M. and Wyckoff, H.W. (1973), in Atlas of Molecular Structures in Biology, Phillips, D.C., and Richards, F.M., Ed., Clarendon Press, Oxford, P. 1.Google Scholar
  6. Schimmel, P.R., Budzik, G.P., Lam, S.S.M., and Schoemaker, H.J.P. (1976), in Aging, Carcinogenesis, and Radiation Biology, Smith, K.C., Ed., New York, Plenum Press, P. 123.CrossRefGoogle Scholar
  7. Schott, H.N. and Shetlar, M.D. (1974), Biochem. Biophys. Res. Commun., 59, 1112.CrossRefGoogle Scholar
  8. Shetlar, M.D., Schott, H.N., Martinson, H.G., and Lin, E.T. (1975), Biochem. Biophys. Res. Commun., 66, 88.CrossRefGoogle Scholar
  9. Smith, K.C. (1969), Biochem. Biophys. Res. Commun., 34, 354.CrossRefGoogle Scholar
  10. Smith, K.C. (1976), in Aging, Carcinogenesis, and Radiation Biology, Smith, K.C., Ed., New York, Plenum Press, P. 67.CrossRefGoogle Scholar
  11. Sperling, J. and Elad, D. (l97l), J. Amer. Chem. Soc., 93, 967.Google Scholar
  12. Sperling, J. (1976), Photochem. Photobiol., 23, 323.CrossRefGoogle Scholar
  13. Sperling, J. and Havron, A. (1976), Biochemistry, 15, 1489.CrossRefGoogle Scholar
  14. Varghese, A.J. (1974), Biochim. Biophys. Acta, 374, 109.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1977

Authors and Affiliations

  • Joseph Sperling
    • 1
  • Abraham Havron
    • 1
  1. 1.Department of Organic ChemistryThe Weizmann Institute of ScienceRehovotIsrael

Personalised recommendations