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Mechanisms for Radiation Damage in DNA Constituents and DNA

  • Michael D. Sevilla
Conference paper
Part of the The Jerusalem Symposia on Quantum Chemistry and Biochemistry book series (JSQC, volume 10)

Abstract

The initial effects of all forms of ionizing radiation on DNA are the production of positive ions, negative ions and excited states of the DNA bases. These species may later react to produce biologically significant damage. Ion radicals in γ-irradiated DNA have been reported.1−3 For example Gräslund, Ehrenberg, Rupprecht, and Ström suggest an anion radical on thymine and a cation radical on guanine in γ-irradiated oriented DNA at 77 K.1 The reactions of these ion radicals produced individually in DNA bases have been recently investigated with some success.4−10 In this discussion we will concentrate on the initial events immediately after ionization i.e. the fate of the electron and positive hole in irradiated DNA.

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Copyright information

© Springer Science+Business Media Dordrecht 1977

Authors and Affiliations

  • Michael D. Sevilla
    • 1
  1. 1.Department of ChemistryOakland UniversityRochesterUSA

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