Mechanisms for Radiation Damage in DNA Constituents and DNA
The initial effects of all forms of ionizing radiation on DNA are the production of positive ions, negative ions and excited states of the DNA bases. These species may later react to produce biologically significant damage. Ion radicals in γ-irradiated DNA have been reported.1−3 For example Gräslund, Ehrenberg, Rupprecht, and Ström suggest an anion radical on thymine and a cation radical on guanine in γ-irradiated oriented DNA at 77 K.1 The reactions of these ion radicals produced individually in DNA bases have been recently investigated with some success.4−10 In this discussion we will concentrate on the initial events immediately after ionization i.e. the fate of the electron and positive hole in irradiated DNA.
Unable to display preview. Download preview PDF.
- 1.A. Gräslund, A. Ehrenberg, A. Rupprecht and G. Ström, Biochem. Biophys. Acta, 254, 172 (1971).Google Scholar
- 8.M. D. Sevilla and M. Engelhardt, Discussions of the Faraday Society, in press.Google Scholar
- 23.G. Scholes in “Radiation Chemistry of Aqueous Systems,” G. Stein Ed., Interscience, New York, N.Y., 1968.Google Scholar