Oxygen transport in the critically ill patient
Molecular oxygen is necessary for all biological systems to function in a proper manner. Aberrations in the supply and utilization of oxygen produce profound changes in the cell metabolism and threaten its survival. Abnormalities of oxygen supply and utilization cut across a broad spectrum of disease entities and pathological states, and very often are the predominant causes of death. Yet, early recognition and prompt treatment of the hypoxic state are not given the importance in clinical medicine as they should. It has been shown that prompt recognition and treatment of the hypoxic state improve the survival of the critically ill patient. The onset of hypoxia in many diseases is very insidious, and the clinical recognition is difficult. There is a universal tendency for physicians to ignore its early warning signs and its many manifestations until it is too late.
Unable to display preview. Download preview PDF.
- 3.Ledingham IMcA: Factors influencing oxygen availability. J Clin Pathol [Suppl] 30, February 1977.Google Scholar
- 4.Robin ED: Dysoxia, abnormal tissue oxygen utilization. Arch Intern Med 137, July 1977.Google Scholar
- 5.Robin ED: Men and mitochondria: coping with hypoxic dysoxia. The 1980 J Burns Amberson Lecture. Am Rev Respir Dis 122, 1980.Google Scholar
- 6.Scadding, Cumming: Scientific foundations of respiratory medicine. Philadelphia: WB Saunders, 1981.Google Scholar
- 7.Silver IA, Erecinska M, Bicher HI (eds): Oxygen transport to tissue — II. AdvExp Med Biol 94.Google Scholar