Molecular mechanisms of pulmonary oxygen toxicity
The toxicity of oxygen was realized shortly after discovery of the gas itself approximately 200 years ago . Approximately a century later, the classic central nervous system pathology was described by Bert  and, shortly thereafter, the pulmonary pathology by Lorrain-Smith . A renewed interest in the toxicity of this gas has developed during the past 20 years because technical advances in oxygen delivery systems have permitted increased use of high concentrations of oxygen for medical therapy. Increasing undersea operations and aerospace exploration have also generated the need for a greater understanding of oxygen toxicity.
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