Paraneoplastic Syndromes

  • Robert A. Nagourney
  • Paul V. Woolley
Part of the Cancer Growth and Progression book series (CAGP, volume 3)


The effects of cancer upon the host are varied and complex. In addition to direct tumor invasion, obstruction of vital organs and metastatic spread, tumors can elaborate soluble factors and humoral substances which influence the ability of the host to function normally. These remote effects constitute an assortment of ‘paraneoplastic syndromes’ which have perplexed scientists and clinicians for over a century. In this chapter we will review many of the commonly encountered syndromes, discuss their significance, and attempt to integrate them into the modern concept of oncogenesis with specific reference to the emerging understanding of the molecular genetics of cancer. We also refer the interested reader to the many excellent reviews on the topic which have been published in recent years (8, 70, 113, 116, 125, 153, 163, 171).


Nephrotic Syndrome Paraneoplastic Syndrome Acanthosis Nigricans Hypertrophic Osteoarthropathy Ectopic ACTH Production 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers, Dordrecht 1989

Authors and Affiliations

  • Robert A. Nagourney
  • Paul V. Woolley

There are no affiliations available

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