The continuing story of 5-hydroxytryptamine receptors: a 5-HT3 receptor modulates dopamine release from rat striatal slice

  • Patrizio Blandina
  • Joseph Goldfarb
  • Jack Peter Green
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)


To the large number of 5-HT receptors that have been catalogued [1–4] can now be added the 5-HT1D receptor, first described as a binding site [5] and recently shown to be negatively coupled to adenylyl cyclase in the calf substantia nigra [6]. Yet additional 5-HT receptors exist, not only in mammalian smooth muscles and other peripheral tissues [1, 3] but in brain as well. For example, the hippocampus has binding sites (and probably the homologous receptors) for all known 5-HT receptors [5, 7–10]. But some 5-HT-induced excitatory responses in the hippocampus cannot be attributed to any of these receptors. These include a slow depolarization of pyramidal cells which has been attributed to a decrease in a K+ current [11, 12]; a decrease in the calcium-dependent K+ current responsible for the slow after-spike hyperpolarization in pyramidal cells [11, 12]; and a transient increase in population spike amplitude [13].


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Copyright information

© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • Patrizio Blandina
  • Joseph Goldfarb
  • Jack Peter Green

There are no affiliations available

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