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Regional differences in the transduction mechanisms of 5-hydroxytryptamine receptors in the mammalian brain

  • M. Hamon
  • M. B. Emerit
  • S. el Mestikawy
  • M. C. Gallissot
  • H. Gozlan
Chapter
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)

Abstract

During the last ten years, binding studies with selective radioligands have contributed to the present knowledge of central 5-hydroxytryptamine (5-HT) receptors, leading to the identification of membrane-bound specific sites with pharmacological properties expected for such receptors. Three main classes of 5-HT binding sites designated 5-HT1,5-HT2 and 5-HT3 have been identified so far [1], Apparently a single homogeneous population of sites corresponds to each of the two latter classes (at least in the CNS), but clearcut evidence of heterogeneity of 5-HT1 sites has been reported [2]. Thus it could be established that 5-HT1 sites are a mixture of 4 distinct classes of high affinity sites for [3H]5-HT called 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D, whose proportions are extremely variable from one brain area to another, and also from one species to another.

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Copyright information

© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • M. Hamon
  • M. B. Emerit
  • S. el Mestikawy
  • M. C. Gallissot
  • H. Gozlan

There are no affiliations available

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