The human platelet 5-HT2-receptor: an up-date

  • D. de Chaffoy de Courcelles
  • F. de Clerck
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)


Platelets are oval discs 2 to 3 μm in diameter, circulating in the blood. They can adhere to damaged blood vessel walls (adhesion) and stick to each other (aggregation). Platelets contain α -granules, dense bodies, lysosomes, mitochondria and glycogen particles. Three different channel-like structures have been identified: an open canalicular system, a dense tubular system and circumferential microtubules. The platelet plasma membrane resembles, in structure as well as in function, that of cells of other tissue. In the sub-membrane area, platelets have microtubules which support their discoid shape and microfilaments which contain contractile proteins involved in the platelet release reaction. Such a release reaction is provoked by platelet stimulation with excitatory agonists. This results in the appearance in the extracellular space of the content of the granules, the dense bodies and the lysosome-like particles. The α -granules contain secretable platelet proteins, such as fibrinogen, β - thromboglobulin, platelet factor-4 and cationic proteins. The dense bodies mainly contain ATP, ADP, calcium and serotonin. The lysosome-like particles contain acid hydrolases. The extent of secretion of the contents of these different subcellular particles depends upon the nature and the concentration of the challenging agonist. Platelets also biosynthetize and release metabolites from arachidonic acid (see also section 1.2).


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© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • D. de Chaffoy de Courcelles
  • F. de Clerck

There are no affiliations available

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