Vascular pharmacology of 5-hydroxytryptamine in humans

  • Gerald J. Blauw
  • Peter Van Brummelen
  • Pieter A. Van Zwieten
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)


Forty yeas after its discovery the role of 5-hydroxytryptaine (5-HT) in the regulation of vascular tone in man still remains rather obscure. Soon after synthetic 5-HT became available it was shown that this monoamine influences vascular tone in a complex manner. Depending on the type of blood vessel and species investigate, as well as on the dose and route of administration, 5-HT was able to induce either vasodilatation or vasoconstriction [1, 2].


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Copyright information

© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • Gerald J. Blauw
  • Peter Van Brummelen
  • Pieter A. Van Zwieten

There are no affiliations available

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