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The endothelium and the role of 5-hydroxytryptamine in vascular disease

  • Paul M. Vanhoutte
Chapter
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)

Abstract

The vascular actions of 5-hydroxytryptamine (5-HT), originally named serotonin [1], remain difficult to understand, as it causes varying responses depending on the isolated blood vessel or vascular bed studied, or the experimental conditions imposed. The present essay will summarize some of the experiments performed in the author’s laboratory suggesting that the presence of the endothelium helps to determine if the monoamine causes constriction or dilatation of blood vessels. In particular, the emerging role of endothelium-derived vasoactive factors in the mediation of the vascular effects of 5-HT will be addressed. For details and original references not cited here the reader is referred to several earlier reviews on related topics [2–17],

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© Springer Science+Business Media Dordrecht 1990

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  • Paul M. Vanhoutte

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