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Coronary circulation and 5-hydroxytryptamine

  • James A. Angus
  • Archer Broughton
  • Thomas M. Cocks
  • Christine E. Wright
Chapter
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)

Abstract

Coronary vasospasm or Prinzmetal’s variant angina [1] is probably caused by a variety of substances that arise from aggregating platelets, from nerve varicosities or from different cells within the wall itself. It may not however, be simply a matter of identifying some pathological constrictor substance. The vascular reactivity, defined here by the “sensitivity” of the artery to the substance (conveniently taken as the EC50) and by the “range” or magnitude (Emax) of the contraction may have changed considerably in patients with angina pectoris.

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Copyright information

© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • James A. Angus
  • Archer Broughton
  • Thomas M. Cocks
  • Christine E. Wright

There are no affiliations available

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