Coronary circulation and 5-hydroxytryptamine
Coronary vasospasm or Prinzmetal’s variant angina  is probably caused by a variety of substances that arise from aggregating platelets, from nerve varicosities or from different cells within the wall itself. It may not however, be simply a matter of identifying some pathological constrictor substance. The vascular reactivity, defined here by the “sensitivity” of the artery to the substance (conveniently taken as the EC50) and by the “range” or magnitude (Emax) of the contraction may have changed considerably in patients with angina pectoris.
Unable to display preview. Download preview PDF.
- 2.Oates JA, Hawiger J, Ross R (1985): Preface to Interaction of platelets with the vessel wall.Bethesda: Am Physiol SocGoogle Scholar
- 7.Higgings CB, Wexler L, Silverman JF, Hayden WG, Anderson WL, Schroeder JH (1976): Spontaneously and pharmacologically provoked coronary arterial spasm in Prinzmetal variant angina.Radiology119: 521–527.Google Scholar
- 10.Richmond DR. (1979): Results of treatment with verapamil in patients with coronary artery spasm, pp. 94–106 in: Kelly DT (ed),Variant Angina, Diagnosis and Treatment. Sydney, Australia: Hogbin Poole.Google Scholar
- 15.Yokoyama M, Akita H, Mizutani T, Fukazaki H, Watanabe Y (1983): Hyperactivity of coronary arterial smooth muscle in response to ergonovine from rabbits with hereditary hyperlipidemia.CircRes53: 63–71.Google Scholar
- 21.Cohen RA, Shepherd JT, Vanhoutte PM (1983): 5-hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries.Am J Physiol245: H1077– H1080.Google Scholar
- 24.Verbeuren TJ, Jordaens FH, Zonnekeyn LL, Van Hove CE, Coene M-C, Herman AG (1986): Effect of hypercholesterolemia on vascular reactivity in the rabbit. 1. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits.Cirs Res58: 552–564.CrossRefGoogle Scholar
- 28.Houston DS, Shepherd JT, Vanhoutte TM (1985): Adenine nucleotides, serotonin and endothelium-dependent relaxations to platelets.Am J Physiol248: H389–H395.Google Scholar
- 36.Feniuk W, Humphrey PPA, Perren MJ, Watts AD (1985): A comparison of 5-hydroxy- tryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists.Br J Pharmacol86: 697–704.PubMedCrossRefGoogle Scholar
- 37.Martin GR, Leff P, MacLennan SJ, Dougall I (1988): Three types of 5-HT1-like receptors recognised by tryptamine affinity and efficacy fingerprints.Br J Pharmacol95: 626 P.Google Scholar
- 38.Chester A, Arneklo-Nobin B, Bodelsson M, Martin G, Tadjkarinni S, Törnebrandt K, Yacoub M (1988): Characterization of 5-HT receptors in human saphenous vein. Cardiovascular Pharmacology of 5-HT, Amsterdam, October 1988, Abstract p. 57.Google Scholar
- 39.Chester A, Martin GR, Bodelsson M, Arneklo-Nobin B, Törnebrandt K, Martin JF, Yacoub M (1988): Evidence for 5-HT1-like and 5-HT receptors mediating contraction of human epicardial coronary arteries. Cardiovascular Pharmacology of 5-HT, Amsterdam, October 1988, Abstract p. 54.Google Scholar
- 45.Cambridge D, Chappie DJ (1988): Characterisation of the coronary vascular response to 5-HT in vivo using tryptamine analogues. Cardiovascular Pharmacology of 5-HT, Amsterdam, October 1988, Abstract p. 56.Google Scholar