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Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (±) 8-OH-DPAT in anaesthetized dogs

  • Michel Laubie
  • Madeleine Drouillat
  • Hubert Dabiré
  • Claudie Cherqui
  • Henri Schmitt
Chapter
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)

Abstract

The central 5-HT1A agonist, 8-OH-DPAT has been reported to produce dose-related decreases in blood pressure and heart rate in anaesthetized rats [1, 3]. The hypotensive effect of 8-OH-DPAT appears to be due to a central sympatho-inhibitory effect [4, 5] and these effects are antagonized by spiperone [5], metergoline [3] and (-) pindolol [6] indicating that the decrease in sympathetic tone produced by 8-OH-DPAT is probably due to the stimulation of central 5-HT1A receptors. The propose of the present work was mainly to localize the sites of action of 8-OH-DPAT in the CNS.

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References

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Copyright information

© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • Michel Laubie
  • Madeleine Drouillat
  • Hubert Dabiré
  • Claudie Cherqui
  • Henri Schmitt

There are no affiliations available

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