Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (±) 8-OH-DPAT in anaesthetized dogs
The central 5-HT1A agonist, 8-OH-DPAT has been reported to produce dose-related decreases in blood pressure and heart rate in anaesthetized rats [1, 3]. The hypotensive effect of 8-OH-DPAT appears to be due to a central sympatho-inhibitory effect [4, 5] and these effects are antagonized by spiperone , metergoline  and (-) pindolol  indicating that the decrease in sympathetic tone produced by 8-OH-DPAT is probably due to the stimulation of central 5-HT1A receptors. The propose of the present work was mainly to localize the sites of action of 8-OH-DPAT in the CNS.
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- 1.Gradin K, Petterson A, Hedner T, Persson B (1985): Acute administration of 8-hydroxy- 2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective 5-HT receptor agonist, causes a biphasic blood pressure response and a bradycardia in the normotensive Sprague-Dawley rat in the spontaneously hypertensive rat. J Neural Transm 62: 305.PubMedCrossRefGoogle Scholar