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Acute and long-term effects of 5-hydroxytryptamine in isolated renal arteries in vitro

  • J. G. R. de Mey
  • M. P. Uitendaal
  • H. C. M. Boonen
  • M. J. J. F. Vrijdag
Chapter
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)

Abstract

Acute changes in vascular function are brought about by changes in the contractile reactivity of vascular smooth muscle. In chronic modulation of vascular function structural alterations of the vascular wall can participate as well (for review, see [1]). Similarly, the responsiveness of the arterial wall to lumenal injury in vivo consists of vasoconstriction and subsequent migration and proliferation of arterial smooth muscle cells (for review, see [2]). The exact relationship between fast responses such as constriction and the slower structural alterations is however unclear.

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Copyright information

© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • J. G. R. de Mey
  • M. P. Uitendaal
  • H. C. M. Boonen
  • M. J. J. F. Vrijdag

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