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5-Hydroxytryptamine receptor antagonists as antihypertensive drugs

  • Pramod R. Saxena
Chapter
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)

Abstract

Though 5-hydroxytryptamine (5-HT) exerts powerful pharmacological effects on the heart and blood vessels [1, 2], the physiological role of 5-HT in cardiovascular regulation is not clear. The effect of 5-HT on arterial blood pressure is triphasic [3] and consists mainly of an initial short-lasting depressor phase due to the Von Bezold-Jarisch reflex mediated by 5-HT3 receptors [4–7], followed by a 5-HT2 receptor-mediated hypertensive phase [5, 6, 8], and a late, long-lasting, hypotensive phase mediated by 5-HT1like receptor stimulation [see 9]. It is, therefore, obvious that only antagonists at 5-HT2 receptors may be expected to have an antihypertensive effect in the event that these receptors are involved in the pathophysiology of hypertension.

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Copyright information

© Springer Science+Business Media Dordrecht 1990

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  • Pramod R. Saxena

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