5-Hydroxytryptamine transport systems

  • David Graham
  • Salomon Z. Langer
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)


Studies on the uptake of radioactively-labelled 5-hydroxytryptamine (5-HT) have revealed the accumulation of this biogenic amine in a number of different tissues. In many instances this accumulation of 5-HT represents a temperature-dependent, saturable uptake process which can be inhibited by metabolic inhibitors and by certain selectively-acting compounds. These observations indicate the presence of specific carrier or transport systems involved in the active transport of 5-HT into specific tissue elements.


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© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • David Graham
  • Salomon Z. Langer

There are no affiliations available

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