Presence of 5-hydroxytryptamine in adrenergic nerves of the brain circulation: its role in sympathetic neurotransmission and regulation of the cerebral vessel wall

  • Christer Owman
  • Jing-Yu Chang
  • Jan Erik Hardebo
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)


It has for long been believed that 5-hydroxytryptamine (5-HT) plays an aetiological role in some important cerebral vascular disorders, such as migraine and vasospasm following subarachnoid hemorrhage [1–6]. This is related to the strong vasoconstrictor action of 5-HT on brain vessels in vitro [7, 8]. When infused into the carotid artery, it reduces cerebral blood flow in many brain regions, provided the blood-brain barrier is opened or monoamine oxidase is inhibited. The response seems to be partly associated with a decrease in cerebral metabolism [9–11].


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© Springer Science+Business Media Dordrecht 1990

Authors and Affiliations

  • Christer Owman
  • Jing-Yu Chang
  • Jan Erik Hardebo

There are no affiliations available

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