The distribution and biochemistry of 5-hydroxytryptamine in the cardiovascular system

  • Tony J. Verbeuren
Part of the Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine book series (DICM, volume 106)


In most plants and animals, significant levels of 5-HT are present. In mammals, the enterochromaffin cells of the gastrointestinal mucosa, the brain, the pineal gland and the platelets contain important concentrations of 5-HT. The indoleamine has also been detected in peripheral nerves of the gut, in lung, kidney, spleen, thyroid, mast cells, heart and blood vessels of different species. It is well accepted that 5-HT has a role as a neurotransmitter in the brain and as a precursor of melatonin in the pineal gland; its precise function in the other tissues in which it is present has yet to be elucidated.


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© Springer Science+Business Media Dordrecht 1990

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  • Tony J. Verbeuren

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