Neutrophil Defensins in Lung Inflammation

  • H. Zhang
  • T. Whitehead
Conference paper


Defence against infection involves a multitude of factors and cells of the innate and acquired immune systems. Antimicrobial peptides, which include the defensins, are one component of innate immunity. Defensins have well documented bactericidal properties. In addition, recent studies have suggested that defensins have other, pro-inflammatory, activities. Furthermore there is evidence that defensins can damage host tissue, and may contribute to the pathogenesis of some conditions. This review summarises the recent developments in defensin biology that are important in understanding their role in lung infection and inflammation.


Bacterial Meningitis Airway Epithelial Cell Human Defensin Human Neutrophil Peptide Peptide Defensin 
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Copyright information

© Springer-Verlag Italia, Milano 2001

Authors and Affiliations

  • H. Zhang
  • T. Whitehead

There are no affiliations available

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