Bronchiolite e asma

  • Augusta Battistini
  • Giuliana Fognani


La letteratura internazionale ha recentemente riconosciuto la mancanza di confini netti fra bronchiolite (BR), wheezing (WH), o respiro sibilante, e asma.


  1. 1.
    Korrpi M (2007) How should we study responses to treatment in children with Bronchiolitis. Pediatr Pulmonol 42:984–985CrossRefGoogle Scholar
  2. 2.
    Cornelli HM, Zore JJ, Majahan P et al (2007) A multicenter randomized controlled trial of Dexamethazone for bronchiolitis. N Engl J Med 357:331–339CrossRefGoogle Scholar
  3. 3.
    Martinez F (2009) Managing childhood asthma: Challenge of preventing exacerbation. Pediatrics 123:S146–S150PubMedCrossRefGoogle Scholar
  4. 4.
    British Thoracic Society (2008) British Guideline on the management of Asthma. Thorax 63:1–121CrossRefGoogle Scholar
  5. 5.
    Cunningham S, Logan C et al (2008) Effect of an integrated care pathway on acute Asthma/Wheeze in children attending hospital: Cluster randomized trial. J Pediat 152:115–120CrossRefGoogle Scholar
  6. 6.
    Castro-Rodriguez JA, Rodrigo GJ (2009) Efficacy of inhaled corticosteroids in infants and preschoolers with recurrent Wheezing and asthma: A systematic review with meta-analysis. Pediatrics 123:e519–e525PubMedCrossRefGoogle Scholar
  7. 7.
    Bianchi M, Clavenna A et al (2009) Anti-asthmatic drug prescription to an italian paediatrics population. Pediatr Allergy Immunol 20:585–591PubMedCrossRefGoogle Scholar
  8. 8.
    Mansbach JM, Espinola JA (2009) Variability in the diagnostic labeling of non bacterial Lower Respiratory Tract infections: A multicenter study of children who presented to the Emergency Departement. Pediatrics 123:e573–e581PubMedCrossRefGoogle Scholar
  9. 9.
    American Academy of Pediatrics (2006) Diagnosis and Management of Bronchiolitis. Pediatrics 118:1774–1793CrossRefGoogle Scholar
  10. 10.
    Gadomski AM, Bhasale AL (2006) Bronchodilator for bronchiolitis. Cochrane Database Syst Rev 3:CD001266Google Scholar
  11. 11.
    Modl M, Eber E et al (2005) Does bronchodilator responsiveness in infants whith bronchiolitis depend on age? J Pediatr 147:617–621PubMedCrossRefGoogle Scholar
  12. 12.
    Teeratakulpisarn J, Limwattananon C (2007) Efficacy of dexamethasone injection for acute bronchiolitis in hospitalized children: A randomized, double-blind, placebo controlled trial. Pediatr Pulmonol 42:433–439PubMedCrossRefGoogle Scholar
  13. 13.
    Bentur L, Shoseyov D (2005) Dexamethasone inhalations in RSV bronchiolitis: A double-blind, placebo controlled study. Acta Paediatr 94:866–871PubMedCrossRefGoogle Scholar
  14. 14.
    Plint AC, Johnson DW (2009) Epinephrine and Dexamethazone in children with bronchiolitis. New E Journal M 360:2079–2089CrossRefGoogle Scholar
  15. 15.
    Volovitz B (2008) Management of acute asthma exacerbations in children. Expert Rev Clin Imunol 4:607–612Google Scholar
  16. 16.
    Spycher BD, Silverman M, Brooke AM et al (2008) Distinguishing phenotypes of childhood wheeze and cough using latent class analysis. Eur Respir 31:974–981CrossRefGoogle Scholar
  17. 17.
    Global Initiative for Asthma (2008) GINA Pocket Guide for asthma management and prevention. Updated 2008. http://www.ginasthma.orgGoogle Scholar
  18. 18.
    National Heart, Lung and Blood Institute; National Institutes of Health (2007) Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Scholar
  19. 19.
    Kondo N (2010) Japanese pediatric gudelines for the traitment and management of bronchial asthma. Pediatrics International 52:319–326PubMedCrossRefGoogle Scholar
  20. 20.
    Ni Chroinin M, Greenstone I, Lasserson TJ, Ducharme FM (2009) Addition of inhaled long acting beta2-agonists to inhaled steroids as first line therapy for persistent asthma in steroid-naïve adults and children. Cochrane Database Syst Rev 7:CD005307Google Scholar
  21. 21.
    Lemanske RF, Mauger D, Sorkness CA et al (2010) Stepup therapy for children with uncontrolled asthma while receiving inhaled corticosteroids. N Engl J Med 362:975–985PubMedCrossRefGoogle Scholar
  22. 22.
    Ducharme FM, Lemire C (2009) Preemptive use of high-dose Fluticasone for virus-induced Wheezing in young children. N Engl J Med 360:339–353PubMedCrossRefGoogle Scholar
  23. 23.
    Rodrigo GJ (2006) Rapid effects of inhaled Corticosteroids in acute asthma. An Evidence Based Evaluation. Chest 130:1301–1311PubMedCrossRefGoogle Scholar
  24. 24.
    Toogood JH, Baskerville J, Jennings B et al (1989) Bioequivalent doses of budesonide and prednisone in moderate and severe asthma. J Allergy Clin Immunol 84:688–700PubMedCrossRefGoogle Scholar
  25. 25.
    Naspitz CK, Croop GJ (2009) Recommendation for treatment of intermittent mild persistent asthma in children and adolescents. Pediatr Pulmonol 44:205–208PubMedCrossRefGoogle Scholar
  26. 26.
    Bisgaard H, Le Roux P, Bjåmer D et al (2006) Budesonide/ Formoterol maintenance plus reliever therapy. Chest 130:1733–1743PubMedCrossRefGoogle Scholar
  27. 27.
    Crilly JA (2009) Holding chambers (spacers) versus nebuliser for beta-agonist treatment of acute asthma. Cochrane Database Syst Rev 19:CD000052Google Scholar
  28. 28.
    Lavorini F, Magnan A (2008) Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med 102:593–604PubMedCrossRefGoogle Scholar
  29. 29.
    Taylor DR, Iijnenburg MW, Smith AD (2006) Exhaled nitric oxide measurement: Clinical application and interpretation. Thorax 61:817–827PubMedCrossRefGoogle Scholar
  30. 30.
    Hansen R, Gartlehner G, Carson SS et al (2005) Drug class review on inhaled corticosteroids. Evidence Report — Oregon Drug Class Review ProjectGoogle Scholar
  31. 31.
    Nieto A, Mazon A (2007) Adverse effects of inhaled corticosteroids in funded and nonfunded studies. Arch Intern Med 167:2047–2053PubMedCrossRefGoogle Scholar
  32. 32.
    Adams N, Lasserson TJ, Cates CJ, Jones PW (2006) Fluticasone versus beclomethasone or budesonide for chronic asthma in adults and children. Cochrane Database Syst Rev 17:CD002310Google Scholar
  33. 33.
    de Vries TW, de Langen-Wouterse JJ, van Puijenbroek E et al (2006) Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Nederlands. Eur J Clin Pharmaco 62:343–346CrossRefGoogle Scholar
  34. 34.
    Smyth RM, Openshaw PJM (2006) Bronchiolitis. Lancet 368:312–322PubMedCrossRefGoogle Scholar
  35. 35.
    Seiden JA, Scarfone RJ (2009) Bronchiolitis: An evidence based approach to management. Clin Ped Emerg Med 10:75–81CrossRefGoogle Scholar
  36. 36.
    Kuzik BA, Al Qadhi SA, Kent S (2007) Nebulised hypetonic saline in the treatment of viral bronchiolitis in infant. J Pediatr 151:266–270PubMedCrossRefGoogle Scholar
  37. 37.
    Liet JM, Ducruet T, Gupta V, Cambonie G (2010) Heliox inhalation therapy for bronchiolitis in infant. Cochrane Database Syst Rev 4:CD006915Google Scholar
  38. 38.
    Gupta VK, Cheifetz IM (2005) Heliox administration in the pediatric intensive care unit: An evidence—based review. Pediatric Crit Care Med 6:204–211CrossRefGoogle Scholar
  39. 39.
    Carrol CL (2009) Non Invasive Ventilation for the treatment of acute lower respiratory tract diseases in children. Clin Ped Emerg Med 10:90–94CrossRefGoogle Scholar
  40. 40.
    Mayordomo Calungo J, Medina A, Rey C et al (2010) Helmet-delivered continous positive airways pressure with Heliox in respiratory syncitial virus bronchiolitis. Acta Paed 99:308–311Google Scholar
  41. 41.
    Greough A (2009) Role of ventilation in RSV disease: CPAP, ventilation, HFO, ECMO. Paediatric Resp Reviews 10: 26–28CrossRefGoogle Scholar
  42. 42.
    Berner ME, Hanquinet S, Rimensberger PC (2008) High frequency oscillatory ventilation for respiratory failure due to RSV bronchiolitis. Intensive Care Med 34:1698–1702PubMedCrossRefGoogle Scholar
  43. 43.
    Duffet M, Choong K, Viavian NG et al (2007) Surfactant therapy for acute respiratory failure in children: A systematic review and meta-analysis. Crit Care 11:R66CrossRefGoogle Scholar
  44. 44.
    Meert KL, Clark J, Sarnaik AP (2007) Metabolic acidosis as an underlying mechanism of respiratory distress in children with severe acute asthma. Pediatr Crit Care Med 8:519–523PubMedCrossRefGoogle Scholar
  45. 45.
    Mohammed S, Goodace S (2007) Intravenous and nebulised magnesium sulphate in acute asthma systemic review and metaanalysis. Emerg Med J 24:823–830PubMedCrossRefGoogle Scholar
  46. 46.
    Wheeler DS, Jacobs BR, Keinregh C et al (2005) Theophilline versus terbutaline in treating critically ill children with status asthmaticus: prospettive, randomized, controlled trial. Pediatr Crit Care Med 62:142–147CrossRefGoogle Scholar
  47. 47.
    Denmark TH, Crane HA, Brown L (2006) Ketamine to avoid mechanical ventilation in severe pediatric asthma. J Emerg Med 30:163–166PubMedCrossRefGoogle Scholar
  48. 48.
    Carrol CL, Smith SR, Collins MS et al (2007) Endotracheal intubation and pediatric status asthmaticus: Site of original care affects treatment. Pediatric Crit Care Med 8:91–95CrossRefGoogle Scholar
  49. 49.
    Tobias JD (2008) Therapeutic application and uses of inhalation anesthesia in the pediatric intensive care unit. Pediatr Crit Care Med 9:169–179PubMedCrossRefGoogle Scholar
  50. 50.
    Ebbar KB, Petrillo Alborano T, Coto-Puckett W et al (2009) Experience with use of extracorporeal life support for severe refractory status asthmaticus in children. Crit Care 13:R29Google Scholar

Copyright information

© Springer-Verlag Italia 2012

Authors and Affiliations

  • Augusta Battistini
    • 1
  • Giuliana Fognani
    • 2
  1. 1.Università degli Studi di ParmaParmaItaly
  2. 2.Unità Operativa di Anestesia-RianimazioneAzienda Ospedaliero-Universitaria MeyerFirenzeItaly

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