Common Colds and Respiratory Viruses: Impact on Allergy and Asthma

  • Ioanna M. Velissariou
  • Paraskevi Xepapadaki
  • Nikolaos G. Papadopoulos
Part of the Allergy Frontiers book series (ALLERGY, volume 3)


Respiratory Syncytial Virus Fluticasone Propionate Allergy Clin Immunol Respir Crit Asthma Exacerbation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    McIntosh K, Ellis EF, Hoffman LS, Lybass TG, Eller JJ, Fulqiniti VA (1973) The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic children. J Pediatr 82(4): 578–590PubMedCrossRefGoogle Scholar
  2. 2.
    Dodge RR, Burrows B (1980) The prevalence and incidence of asthma and asthma-like symptoms in a general population sample. Am Rev Respir Dis 122(4): 567–575PubMedGoogle Scholar
  3. 3.
    Papadopoulos NG, Hunter J, Sanderson G, Meyer J, Johnston SL (1999) Rhinovirus identification by BgI I digestion of picornavirus RT-PCR amplicons. J Virol Methods 80: 179–185PubMedCrossRefGoogle Scholar
  4. 4.
    Xepapadaki P, Psarras S, Bossios A, Tsolia M, Gourgiotis D, Liapi-Adamidou G, Constantopoulos AG, Kafetzis D, Papadopoulos NG (2004) Human Metapneumovirus as a causative agent of acute bronchiolitis in infants. J Clin Virol 30: 267–270PubMedGoogle Scholar
  5. 5.
    Strachan DP (1989) Hay fever, hygiene, and household size. BMJ 299: 1259–1260PubMedGoogle Scholar
  6. 6.
    Johnston SL, Sanderson G, Pattemore PK, Smith S, Bardin PG, Bruce CB, Lambden PR, Tyrrell DA, Holgate ST (1993) Use of polymerase chain reaction for diagnosis of picornavirus infection in subjects with and without respiratory symptoms. J Clin Microbiol 31: 111–117PubMedGoogle Scholar
  7. 7.
    Mallia P, Johnston SL (2002) Respiratory viruses: do they protect from or induce asthma? Allergy 57: 1118–1129PubMedCrossRefGoogle Scholar
  8. 8.
    Martinez FD, Morgan WJ, Wright AL, Holberg CJ, Taussig LM (1988) Diminished lung function as a predisposing factor for wheezing respiratory illness in infants. New Engl J Med 319: 1112–1117PubMedCrossRefGoogle Scholar
  9. 9.
    Martinez FD, Stern DA, Wright AL, Taussig LM, Halonen M (1998) Differential immune responses to acute lower respiratory illness in early life and subsequent development of persistent wheezing and asthma. J Allergy Clin Immunol 102: 915–920PubMedCrossRefGoogle Scholar
  10. 10.
    Glezen WP, Taber LH, Frank AL, Kasel JA (1986) Risk of primary infection and reinfection with respiratory syncytial virus. Am J Dis Child 140: 543–546PubMedGoogle Scholar
  11. 11.
    Rooney JC, Williams HE (1971) The relationship between proved viral bronchiolitis and subsequent wheezing. J Pediatr 79: 744–747PubMedCrossRefGoogle Scholar
  12. 12.
    Smyth RL, Fletcher JN, Thomas HM, Hart CA, Openshaw PJM (1999) Respiratory syncytial virus and wheeze [letter]. Lancet 354: 1997–1998PubMedCrossRefGoogle Scholar
  13. 13.
    Tager IB, Hanrahan JP, Tosteson TD, Castile RG, Brown RB, Weiss ST (1993) Lung function, pre- and post-natal smoke exposure, and wheezing in the first year of life. Am Rev Respir Dis 47: 811–817Google Scholar
  14. 14.
    Kattan M (1999) Epidemiologic evidence of increased airway reactivity in children with a history of bronchiolitis. J Pediatr 135: 8–13PubMedCrossRefGoogle Scholar
  15. 15.
    Sigurs N, Bjarnason R, Sigurbergsson F, Kjellman B (2000) Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7. Am J Respir Crit Care Med 161: 1501–1507PubMedGoogle Scholar
  16. 16.
    Toms GL, Quinn R, Robinson JW (1996) Undetectable IgE responses after respiratory syncytial virus infection. Arch Dis Child 74: 126–130PubMedCrossRefGoogle Scholar
  17. 17.
    Stein RT, Sherrill D, Morgan WJ, Holberg CJ, Halonen M, Taussig LM, Wright AL, Martinez FD (1999) Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354: 541–545PubMedCrossRefGoogle Scholar
  18. 18.
    Noble V, Murray M, Webb MS, Alexander J, Swarbrick AS, Milner AD (1997) Respiratory status and allergy nine to 10 years after acute bronchiolitis. Arch Dis Child 76: 315–319PubMedCrossRefGoogle Scholar
  19. 19.
    McConnockie KM, Roghmann KJ (1989) Wheezing at 8 and 13 years: changing importance of bronchiolitis and passive smoking. Pediatr Pulmonol 6: 138–146CrossRefGoogle Scholar
  20. 20.
    Roorda RJ (1996) Prognostic factors for the outcome of childhood asthma in adolescence. Thorax 51(Suppl 1): S7–S12PubMedCrossRefGoogle Scholar
  21. 21.
    van Benten I, Koopman L, Niesters B, Hop W, van Middelkoop B, de Waal L, van Drunen K, Osterhaus A, Neijens H, Fokkens W (2003) Predominence of rhinovirus in the nose of symptomatic and asymptomatic infants. Pediatr Allergy Immunol 14(5): 363–370PubMedCrossRefGoogle Scholar
  22. 22.
    Papadopoulos NG, Moustaki M, Tsolia M, Bossios A, Astra E, Prezerakou A, Gourgiotis D, Kafetzis D (2002) Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am J Respir Crit Care Med 165(9): 1285–1289PubMedCrossRefGoogle Scholar
  23. 23.
    Malmstrom K, Pitkaranta A, Carpen O, Pelkonen A, Malmberg LP, Turpeinen M, Kajosaari M, Sarna S, Lindahl H, Haahtela T, Makela MJ (2006) Human rhinovirus in bronchial epithelium of infants with recurrent respiratory symptoms. J Allergy Clin Immunol 118(3): 591–596PubMedCrossRefGoogle Scholar
  24. 24.
    Lemanske RF Jr, Jackson DJ, Gangnon RE, Evans MD, Li Z, Shult PA, Kirk CJ, Reisdorf E, Roberg KA, Anderson EL, Carlson-Dakes KT, Adler KJ, Gilbertson-White S, Pappas TE, Dasilva DF, Tisler CJ, Gern JE (2005) Rhinovirus illnesses during infancy predict subsequent childhood wheezing. J Allergy Clin Immunol 116(3): 571–577PubMedCrossRefGoogle Scholar
  25. 25.
    Aberle JH, Aberle SW, Dworzak MN, Mandl CW, Rebhandl W, Vollnhofer G, Kundi M, Popow-Kraupp T (1999) Reduced interferon-gamma expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease. Am J Respir Crit Care Med 160: 1263–1268PubMedGoogle Scholar
  26. 26.
    Openshaw PJ, Lemanske RF (1998) Respiratory viruses and asthma: can the effects be prevented? Eur Respir J (Suppl 27): 35–39Google Scholar
  27. 27.
    Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO (2003) Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med 168(6): 633–639PubMedCrossRefGoogle Scholar
  28. 28.
    Rodriguez WJ, Arrobio J, Fink R, Kim HW, Milburn C (1999) Prospective follow-up and pulmonary functions from a placebo-controlled randomized trial of ribavirin therapy in respiratory syncytial virus bronchiolitis : Ribavirin Study Group. Arch Pediatr Adolesc Med 153: 469–474PubMedGoogle Scholar
  29. 29.
    Papadopoulos NG, Psarras S (2003) Rhinoviruses in the pathogenesis of asthma. Curr Allergy Asthma Rep 3: 137–145PubMedCrossRefGoogle Scholar
  30. 30.
    Openshaw PJ, Hewitt C (2000) Protective and harmful effects of viral infections in childhood on wheezing disorders and asthma. Am J Respir Crit Care Med 162: 540–543Google Scholar
  31. 31.
    Illi S, von Mutius E, Lau S, Bergmann R, Niggemann B, Sommerfeld C Wahn U:MAS Group (2001) Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 322: 390–395PubMedCrossRefGoogle Scholar
  32. 32.
    McKeever TM, Lewis SA, Smith C, Collins J, Heatlie H, Frischer M, Hubbard R (2002) Early exposure to infections and antibiotics and the incidence of allergic disease: a birth cohort study with the West Midlands General Practice Research Database. J Allergy Clin Immunol 109: 43–50PubMedCrossRefGoogle Scholar
  33. 33.
    Celedon JC, Litonjua AA, Ryan L, Weiss ST, Gold DR (2002) Day care attendance, respiratory tract illnesses, wheezing, asthma, and total serum IgE level in early childhood. Arch Pediatr Adolesc Med 156: 241–245PubMedGoogle Scholar
  34. 34.
    Bager P, Westergaard T, Rostgaard K, Hjalgrim H, Melbye M (2002) Age at childhood infections and risk of atopy. Thorax 57: 379–382PubMedCrossRefGoogle Scholar
  35. 35.
    Papadopoulos NG, Foteinos G (2007) Is allergy a result or a modifier of viral infections? An incoordination hypothesis. Allergy Clin Immunol Int (in press)Google Scholar
  36. 36.
    Pattemore PK, Johnston SL, Bardin PG (1992) Viruses as precipitants of asthma symptoms: I. Epidemiology. Clin Exp Allergy 22: 325–336CrossRefGoogle Scholar
  37. 37.
    Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, Symington P, O'Toole S, Myint SH, Tyrrell DA (1995) Community study of role of viral infections in exacerbations of asthma in 9–11 year old children. BMJ 310: 1225–1228PubMedGoogle Scholar
  38. 38.
    Freymuth F, Vabret A, Brouard J, Toutain F, Verdon R, Petitjean J, Gouarin S, Duhamel JF, Guillois B (1999) Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniaeinfections in exacerbations of asthma in children. J Clin Virol 13: 131–139PubMedCrossRefGoogle Scholar
  39. 39.
    Nicholson KG, Kent J, Ireland DC (1993) Respiratory viruses and exacerbations of asthma in adults. BMJ 307: 982–986PubMedCrossRefGoogle Scholar
  40. 40.
    Atmar RL, Guy E, Guntupalli KK, Zimmerman JL, Bandi VD, Baxter BD, Greenberg SB (1998) Respiratory tract viral infections in inner-city asthmatic adults. Arch Intern Med 158: 2453–2459PubMedCrossRefGoogle Scholar
  41. 41.
    Ong BH, Gao Q, Phoon MC, Chow VT, Tan WC, Van Bever HP (2007) Identification of human metapneumovirus and Chlamydophila pneumoniae in children with asthma and wheeze in Singapore. Singapore Med J 48(4): 291–293PubMedGoogle Scholar
  42. 42.
    Joao SM, Ferraz C, Pissarra S, Cardoso MJ (2007) Role of viruses and atypical bacteria in asthma exacerbations among children in Oporto (Portugal). Allergol Immunopathol (Madr) 35(1): 4–9CrossRefGoogle Scholar
  43. 43.
    Jartti T, Lehtinen P, Vuorinen T, Osterback R, van der Hoogen B, Osterhaus AD, Ruuskanen O (2004) Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children. Emerg Infect Dis 10(6): 1095–1101PubMedGoogle Scholar
  44. 44.
    Johnston SL, Pattemore PK, Sanderson G, Smith S, Campbell MJ, Josephs LK, Cunningham A, Robinson BS, Myint SH, Ward ME, Tyrrell DA, Holgate ST (1996) The relationship between upper respiratory infections and hospital admissions for asthma: a time-trend analysis. Am J Respir Crit Care Med 154: 654–660PubMedGoogle Scholar
  45. 45.
    Johnston NW, Johnston SL, Norman GR, Dai J, Sears MR (2006) The September epidemic of asthma hospitalization: school children as disease vectors. J Allergy Clin Immunol 117(3): 557–562PubMedCrossRefGoogle Scholar
  46. 46.
    Campbell MJ, Holgate ST, Johnston SL (1997) Trends in asthma mortality: data on seasonality of deaths due to asthma were omitted from paper but editorial' s author did not know [letter]. BMJ 315: 1012PubMedGoogle Scholar
  47. 47.
    Empey DW, Laitinen LA, Jacobs L, Gold WM, Nadel JA (1976) Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis 113: 131–139PubMedGoogle Scholar
  48. 48.
    Folkerts G, Busse WW, Nijkamp FP, Sorkness R, Gern JE (1998) Virus-induced airway hyperresponsiveness and asthma. Am J Respir Crit Care Med 157: 1708–1720PubMedGoogle Scholar
  49. 49.
    Grunberg K, Timmers M, Smits H, de Klerk EP, Dick EC, Spaan WJ, Hiemstra PS, Sterk PJ (1997) Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy 27: 36–45PubMedCrossRefGoogle Scholar
  50. 50.
    Grunberg K, Timmers MC, de Klerk EP, Dick EC, Sterk PJ (1999) Experimental rhinovirus 16 infection causes variable airway obstruction in subjects with atopic asthma. Am J Respir Crit Care Med 160: 1375–1380PubMedGoogle Scholar
  51. 51.
    Gern J, Calhoun W, Swenson C, Shen G, Busse WW (1997) Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects. Am J Respir Crit Care Med 155: 1872–1876PubMedGoogle Scholar
  52. 52.
    Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, Yagi S, Boushey HA (1999) Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med 160: 100–108PubMedGoogle Scholar
  53. 53.
    Lemanske RF Jr, Dick EC, Swenson CA, Vrtis RF, Busse WW (1989) Rhinovirus upper respiratory infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest 83: 1–10PubMedCrossRefGoogle Scholar
  54. 54.
    Calhoun W, Dick E, Schwartz L, Busse W (1994) A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects. J Clin Invest 94: 2200–2208PubMedCrossRefGoogle Scholar
  55. 55.
    Avila PC, Abisheganaden JA, Wong H, Liu J, Yagi S, Schnurr D, Kishiyama JL, Boushey HA (2000) Effects of allergic inflammation of the nasal mucosa on the severity of rhinovirus 16 cold. J Allergy Clin Immunol 105: 923–932PubMedCrossRefGoogle Scholar
  56. 56.
    Busse WW, Gern JE (2000) Do allergies protect against the effects of a rhinovirus cold? [editorial]. J Allergy Clin Immunol 105: 889–891PubMedCrossRefGoogle Scholar
  57. 57.
    Bossios A, Psarras S, Gourgiotis D, Skevaki CL, Constantopoulos AG, Saxoni-Papageorgiou P, Papadopoulos NG (2005) Rhinovirus infection induces cytotoxicity and delays wound healing in bronchial epithelial cells. Respir Res 6: 114PubMedCrossRefGoogle Scholar
  58. 58.
    Schroth MK, Grimm E, Frindt P, Galagan DM, Konno SI, Love R, Gern JE (1999) Rhinovirus replication causes RANTES production in primary bronchial epithelial cells. Am J Respir Cell Mol Biol 20: 1220–1228PubMedGoogle Scholar
  59. 59.
    Papadopoulos NG, Bates PJ, Bardin PG, Papi A, Leir SH, Fraenkel DJ, Meyer J, Lackie PM, Sanderson G, Holgate ST, Johnston SL (2000) Rhinoviruses infect the lower airways. J Infect Dis 181 : 1875–1884PubMedCrossRefGoogle Scholar
  60. 60.
    Gern JE, Galagan DM, Jarjour NN, Dick EC, Busse WW (1997) Detection of rhinovirus RNA in lower airway cells during experimentally induced infection. Am J Respir Crit Care Med 155: 1159–1161PubMedGoogle Scholar
  61. 61.
    Subauste MC, Jacoby DB, Richards SM, Proud D (1995) Infection of a human respiratory epithelial cell line with rhinovirus: induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 96: 549–557PubMedCrossRefGoogle Scholar
  62. 62.
    Olszewska-Pazdrak B, Casola A, Saito T, Alam R, Crowe SE, Mei F, Oqra PL, Garofalo RP (1998) Cell-specific expression of RANTES, MCP-1, and MIP-1alpha by lower airway epithelial cells and eosinophils infected with respiratory syncytial virus. J Virol 72: 4756–4764PubMedGoogle Scholar
  63. 63.
    Jacoby DB, Fryer AD (1999) Interaction of viral infections with muscarinic receptors. Clin Exp Allergy 29(Suppl 2): 59–64PubMedGoogle Scholar
  64. 64.
    Jacoby DB, Tamaoki J, Borson DB, Nadel JA (1988) Influenza infection causes airway hyper-responsiveness by decreasing enkephalinase. J Appl Physiol 64: 2653–2658PubMedGoogle Scholar
  65. 65.
    Grunberg K, Kuijpers E, de Klerk E, de Gouw HW, Kroes AC, Dick EC, Sterk PJ (1997) Effects of experimental rhinovirus 16 infection on airway hyperresponsiveness to bradykinin in asthmatic subjects in vivo. Am J Respir Crit Care Med 155: 833–838PubMedGoogle Scholar
  66. 66.
    Spender LC, Hussell T, Openshaw PJ (1998) Abundant IFN-gamma production by local T cells in respiratory syncytial virus-induced eosinophilic lung disease. J Gen Virol 79: 1751–1758PubMedGoogle Scholar
  67. 67.
    Matsuse H, Behera AK, Kumar M, Rabb H, Lockey RF, Mohapatra SS (2000) Recurrent respiratory syncytial virus infections in allergen-sensitized mice lead to persistent airway inflammation and hyperresponsiveness. J Immunol 164: 6583–6592PubMedGoogle Scholar
  68. 68.
    Coyle AJ, Erard F, Bertrand C, Walti S, Pircher H, Le Gros G (1995) Virus-specific CD8 cells can switch to interleukin 5 production and induce airway eosinophilia. J Exp Med 181: 1229–1233PubMedCrossRefGoogle Scholar
  69. 69.
    Moran TM, Isobe H, Fernandez-Sesma A, Schulman JL (1996) Interleukin-4 causes delayed virus clearance in influenza virus-infected mice. J Virol 70: 5230–5235PubMedGoogle Scholar
  70. 70.
    Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL (2002) A defective type 1 response to rhinovirus in atopic asthma. Thorax 57(4):328–332.PubMedCrossRefGoogle Scholar
  71. 71.
    Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, Holgate ST, Davies DE (2005) Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 201: 937–947PubMedCrossRefGoogle Scholar
  72. 72.
    Holgate ST (2006) Rhinoviruses in the pathogenesis of asthma: the bronchial epithelium as a major disease target. J Allergy Clin Immunol 118: 587–590PubMedCrossRefGoogle Scholar
  73. 73.
    Kling S, Donninger H, Williams Z, Vermeulen J, Weinberg E, Latiff K, Ghildyal R, Bardin P (2005) Persistence of rhinovirus RNA after asthma exacerbation in children. Clin Exp Allergy 35: 672–678PubMedCrossRefGoogle Scholar
  74. 74.
    Crisafi GM, Billmeyer EE, Sorkness RL (2006) The detection of rhinovirus RNA in severe asthma. Proc Am Thorac Soc 3: A15Google Scholar
  75. 75.
    Wilson NM (2003) Virus infections, wheeze and asthma. Paediatr Respir Rev 4(3): 184–192PubMedCrossRefGoogle Scholar
  76. 76.
    Murray CS, Woodcock A, Langley SJ, Morris J, Custovic A, IFWIN study team (2006) Secondary prevention of asthma by the use of Inhaled Fluticasone Propionate in Wheezy Infants (IFWIN): double-blind, randomised, controlled study. Lancet 368(9537): 754–762PubMedCrossRefGoogle Scholar
  77. 77.
    Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD (2000) A clinical index to define risk of asthma in young children with recurrent wheeze. Am J Respir Crit Care Med 162(4 Pt1): 1403–1406PubMedGoogle Scholar
  78. 78.
    Papadopoulos NG, Papi A, Psarras S, Johnston SL (2004) Mechanisms of rhinovirus-induced asthma. Paediatr Respir Rev 5(3): 255–260PubMedCrossRefGoogle Scholar
  79. 79.
    Yamaya M, Sasaki H (2003) Rhinovirus and asthma. Viral Immunol 16(2): 99–109PubMedCrossRefGoogle Scholar
  80. 80.
    Suzuki T, Yamaya M, Sekizawa K, Hosoda M, Yamada N, Ishizuka S, Yoshino A, Yasuda H, Takahashi H, Nishimura H, Sasaki H (2002) Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells. Am J Respir Crit Care Med 165(8): 1113–1118PubMedGoogle Scholar
  81. 81.
    Johnston SL, Blasi F, Black PN, Martin RJ, Farrell DJ, Nieman RB, TELICAST Investigators (2006) The effect of telithromycin in acute exacerbations of asthma. N Engl J Med 354(15): 1589–1600PubMedCrossRefGoogle Scholar
  82. 82.
    Ledford RM, Patel NR, Demenczuk TM, Watanyar A, Herbertz T, Collett MS, Pevear DC (2004) VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds. J Virol 78(7): 3663–3674PubMedCrossRefGoogle Scholar
  83. 83.
    Hayden FG, Turner RB, Gwaltney JM, Chi-Burris K, Gersten M, Hsyn P, Patick AK, Smith GJ 3rd, Zalman LS (2003) Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother 47(12): 3907–3916PubMedCrossRefGoogle Scholar
  84. 84.
    Volonaki E, Psarras S, Xepapadaki P, Psomali D, Gourgiotis D, Papadopoulos NG (2006) Synergistic effects of fluticasone propionate and salmeterol on inhibiting rhinovirus-induced epithelial production of remodelling-associated growth factors. Clin Exp Allergy 36(10): 1268–1273PubMedCrossRefGoogle Scholar
  85. 85.
    O'Byrne PM, Bisgaard H, Godard PP, Pistolesi M, Palmqvist M, Zhu Y, Ekstrom T, Bateman ED (2005) Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 17(2): 129–136Google Scholar

Copyright information

© Springer 2009

Authors and Affiliations

  • Ioanna M. Velissariou
    • 1
  • Paraskevi Xepapadaki
    • 1
  • Nikolaos G. Papadopoulos
    • 1
  1. 1.Allergy Research Center, 2nd Pediatric ClinicUniversity of AthensGoudiGreece

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