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Anakinra in rheumatoid arthritis

  • Chapter
Antirheumatic Therapy: Actions and Outcomes

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Interleukin-1 (IL-1) plays a central role in the pathophysiology of rheumatoid arthritis (RA) [1]. The IL-1 gene family includes IL-1α, IL-lβ and IL-1 receptor antagonist (IL-IRa) [2], Extracellular IL-lα, which is membrane-associated, and IL- lβ, which is the soluble form, are agonist molecules that can influence the functions of most cell types. Activated monocytes and macrophages are the principal source of IL-la and IL-lβ. There are two distinct IL-1 receptors, designated type I (IL-1RI) and type II (IL-1RII) [3, 4]. IL-1 binding to IL-1RI results in signal transduction and cell activation. IL-1RII is a “decoy” receptor that functions by scavenging IL-la and IL-lβ, but does not have a role in cell signaling [5]. Soluble IL-1RII (sIL-lRII) is important in regulating IL-l-mediated functions. Binding of IL-1 to IL-1RI produces many effects that are central to the pathogenesis of RA [3, 4, 6–8]. The pivotal role of IL-1 in the pathophysiology of RA was highlighted by inducing the pathologic features of RA in rabbits following transfer of the human IL-lβ gene, resulting in the constitutive expression of IL-lβ by synovial cells [9].

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Author information

Authors and Affiliations

  1. Department of Rheumatology, St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

    Barry Bresnihan

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  1. Barry Bresnihan
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Editors and Affiliations

  1. Department of Clinical Pharmacology and Toxicology, St. Vincent’s Hospital Sydney, Victoria Street Darlinghurst, Sydney, NSW, 2010, Australia

    Richard O. Day

  2. 546 Dept. of Rheumatology, University Hospital Nijmegen, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands

    Piet L. C. M. van Riel

  3. Carl M.Pearson Professor of Rheumatology, 1000 Veteran Ave Rm 32-59, Los Angeles, CA, 90025-1670, USA

    Daniel E. Fürst

  4. Department of Rheumatology, St Vicent’s University Hospital, Elm Park, Dublin 4, Ireland

    Barry Bresnihan

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© 2005 Birkhäuser Verlag Basel/Switzerland

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Bresnihan, B. (2005). Anakinra in rheumatoid arthritis. In: Day, R.O., Fürst, D.E., van Riel, P.L.C.M., Bresnihan, B. (eds) Antirheumatic Therapy: Actions and Outcomes. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7726-7_15

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  • DOI: https://doi.org/10.1007/978-3-7643-7726-7_15

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-6595-0

  • Online ISBN: 978-3-7643-7726-7

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