Toroviruses — members of the coronavirus superfamily?
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During the last twenty years in Utrecht we have focused on the characterization of enveloped positive-stranded RNA viruses, above all on the well-characterized family of coronaviruses, with the mouse hepatitis and feline infectious peritonitis viruses receiving most attention; in addition, less common and not properly classified agents e.g. equine arteritis virus (EAV) and Berne virus (BEV) have been analyzed. It was quite unexpected when nucleotide sequence comparisons suggested that EAV and BEV are phylogenetically related to each other and to coronaviruses; the properties of the latter have been reviewed [16, 17]. The present paper summarizes some data on toroviruses and gives the arguments why these are considered as evolutionarily related with corona- and arteriviruses.
KeywordsEquine Arteritis Virus Ribosomal Frameshifting Feline Infectious Peritonitis Virus Lelystad Virus Subgenomic mRNAs
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