Abstract
It has long been recognized that viruses classified as influenza can show a complete lack of cross-reactivity in their surface antigens. However, all viruses classified as influenza type A have cross-reacting internal components, the matrix and nucleocapsid proteins. Influenza B and C viruses are similar in morphology (Fig. 1) and composition, and in their replication processes, to influenza A viruses. However no antigenic cross reactivity among these viruses has been detected, and they are therefore classified as completely unrelated antigenic types. The morphology of influenza A and B virions is indistinguishable when examined by electron microscopy; on the other hand, influenza C virions exhibit some distinct structural features, which are described in detail in the text which follows.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Air, G. M.: Nucleotide sequence coding for the “signal peptide” and N-terminus of the hemagglutinin from an Asian (H2N2) strain of influenza virus. Virology 97, 468–472 (1979).
Air, G. M., Hackett,]. A.: Gene 8 of influenza virus: sequences ofcDNA transcribed from the 3’ ends of viral RNA of influenza A and B strains. Virology 103, 291–298 (1980).
Apostolov, K., Flewett, T. H., Kendal, A. P.: Morphology of influenza A, B, C, and infectious bronchitis vims (IBV) virions and their replication. In: The Biology of Large RNA Vimses (Barry, R.D., Mahy, B.W.J., eds.), 3–26. 1970.
Baine, W. B., Luby, J. P., Markin, S. M.: Severe illness with influenza B. Am. J. med. 68,181–188 (1980).
Barclay, G. R., Leader-Williams, L. K, Flewett, T. H.: Aspects of influenza C vims rephcation.J. Hyg. 69, 587–592 (1971).
Bentley, D. R., Brownlee, G. G.: SequenceoftheN2 neuraminidase from influenza vims A/NT/60/68. Nucl. Acids Res. 10, 5033–5042 (1982).
Blok, J., Air, G. M.: Variation in membrane-insertion and “stalk” sequences in eight subtypes of influenza type A vims neuraminidase. Biochemistry 21, 4001–4007 (1982a).
Blok, J., Air, G. M.: Sequence variation at the 3’ end of the neuraminidase gene from 39 type A influenza vimses. Virology 121, 211–229 (1982b).
Blok, J., Air, G. M., Laver, W G., Ward, C. W, Lilley, G. G., Woods, E. P., Roxburgh, C. M., Inglis, A. S.: Studies on the size, chemical composition and partial sequence of the neuraminidase (NA) from type A influenza vimses show that the N-terminal region of the NA is not processed and serves to anchor the NA in the viral membrane. Virology 119, 109–121 (1982).
Briedis, D.J., Lamb, R.A., Choppin, P.W,: Influenza B vims RNA segment 8 codes for two nonstmctural proteins. Virology 112, 417–425 (1981).
Briedis, D. J., Lamb, R. A.: The influenza B virus genome: Sequences and stmctural organization of RNA segment 8 and the mRNAs coding for the NSi and NS2 proteins. J. Virol. 42,186–193 (1982).
Briedis, D.J., Lamb, R.A., Choppin, P. W.: Sequence of RNA segment 7 of the influenza B vims genome: partial amino acid homology between the membrane proteins (Ml) of influenza A and B vimses and conservation of a second open reading frame. Virology 116, 581–588 (1982).
Chakraverty, P.: Antigenic relationships between influenza B vimses. Bull. Wld. Hlth. Org. 45, 755–766 (1972).
Choppin, P. W., Lazarowitz, S. G., Goldberg, A. R.: Studies on proteolytic cleavage and glycosylation of the hemagglutinin of influenza A and B vimses. In: Negative Strand Vimses and Host Cell (Barry, R.D., Mahy, B., eds.), 105–119. 1975.
Clerx, J., Clerx van-Haaster, C., Meier-Ewert, H.: Submitted for publication, 1983.
Compans, R. W., Klenk, H. D., Caliguiri, L. A., Choppin, P. W.: Influenza vims proteins. 1. Analysis of polypeptides of the virion and identification of spike glycoproteins. Virology 42, 880–889 (1970).
Compans, R. W., Content, J., Duesberg, P. H.: Stmcture of the ribonucleoprotein of influenza vims. J. Virol. 10, 795–800 (1972).
Compans, R.W., Bishop, D.H.L., Meier-Ewert, H.: Stmctural components of influenza C virions. J. Virol. 21, 658–665 (1977).
Corey, L., Rubin, R. J., Thompson, T R., Noble, G. R., Cassidy, E., Hattwick, M. A. W., Gregg, M. B., Eddins, D.: Influenza B-associated Reye’s syndrome: incidence in Michigan and potential of prevention. J. Infect. Dis. 135, 398–407 (1977).
Desselberger, U., Palese, P.: Molecular weights of RNA segments of influenza A and B vimses. Virology 88, 394–399 (1978).
Desselberger, U., Racaniello, V. R., Zazra, J.J., Palese, P.: The 3’ and 5’ terminal sequences of influenza A, B, and C vims RNA segments are highly conserved and show partial inverted complementarity. Gene 8, 315–328 (1980).
Elder, K. T., Bye, J. M., Skehel, J. J., Waterfield, M. D., Smith, A. E.: In vitro synthesis, glycosylation and membrane insertion of influenza vims hemagglutinin. Virology 95, 343–350 (1979).
Fields, S., Winter, G., Brownlee, G. G.: Stmcture of the neuraminidase gene from human influenza vims A/PR/8/34. Nature (Lond.) 290, 213–217 (1981).
Flewett, T. H., Apostolov, K: A reticular stmcture in the wall of influenza C vims. J. Gen. Virol. 1, 297–304 (1967).
Gething, M.J., White, J. M., Waterfield, M. D.: Purification of the fusion protein of Sendai vims. Analysis of the NH2-terminal sequence generated during precursor activation. Proc. Natl. Acad. Sci. U.S.A. 75, 2737–2740 (1978).
Helenius, A., Kartenbeck, J., Simons, K, Fries, E.: On the entry of SemHki Forest vims into BHK-21 cells. J. Cell Biol. 84, 404–420 (1980).
Herrler, G., Compans, R. W., Meier-Ewert, H.: A precursor glycoprotein in influenza C vims. Virology 99, 49–56 (1979).
Herder, G., Nagele, A., Meier-Ewert, H., Bhown, A. S., Compans, R.W.: Isolation and stmctural analysis of influenza C virion glycoproteins. Virology 113, 439–451 (1981).
Hirst, G. K: The reladonship of the receptors of a new strain of vims to those of the mumps-NDV- influenza group. J. Exp. Med. 91, 177–185 (1950).
Huang, R. T. C., Rott, R., Klenk, H.-D.: Influenza vimses cause hemolysis and fusion of cells. Virology 110, 243–247 (1981).
Hiti, A. L., Nayak, D. P.: Complete nucleotide sequence of the neuraminidase gene of human influenza vims A/WSN/33. J. ViroL 41, 730–734 (1982).
Inglis, S. C., Barrett, T, Brown, C. M., Almond, W.: The smallest genome RNA segment of influenza virus contains two genes that may overlap. Proc. Nat. Acad. Sci. U.S.A. 76, 3790–3794 (1979).
Kendal, A. P.: A comparison of influenza C with prototype myxovimses: Receptor-destroying activity (neuraminidase) and stmctural polypeptides. Virology 65, 87–99 (1975).
Klenk, H.-D., Compans, R. W., Choppin, P. W.: An electron microscopic study of the presence or absence of neuraminic acid in enveloped vimses. Virology 42, 1158–1162 (1970).
Klenk, H.-D., Rott, R., Orlich, M., Biodorn, J.: Activation of influenza A vimses by trypsin treatment. Virology 68, 426–439 (1975).
Kozak, M.: Mechanism of mRNA recognition by eukaryotic ribosomes during initiation of protein synthesis. Current Topics in Microbiol, and Immunol. 93, 81–123 (1981).
Krug, R. M., Broni, B. A., Bouloy, M.: Are the 5’ ends of influenza viral mRNAs synthesizedin vivo donated by host mRNAs? Cell 18, 329–334 (1979).
Krug, R. M., Plotch, S.J., Ulmanen, I., Bouloy, M., Herz, C., Beaton, A.: The initiation of influenza viral RNA transcription by capped RNA primers. In: Genetic Variation Among Influenza Viruses (Nayak, D.P., ed.), 93–112. New York: Academic Press 1981.
Krystal, M., Elliott, R. M., Benz, E. W., Young, J. P., Palese, P.: Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes. Proc. Natl. Sci. 79, 4800–4804 (1982).
Kuo, Y. C., Jin, P., Wang, M., Wang, P., Chu, C. M.: Influenza C virus isolated from pigs in China. Kexue Tongbao 27, 1118–1121 (1982)
Lamb, R. A., Choppin, P. W.: Segment 8 of the influenza virus genome is unique in coding for two polypeptide. Proc. Nat. Acad. Sci. U.S.A. 76, 4908–4912 (1979).
Lamb, R. A., Lai, C.-J.: Sequence of interrupted and unintermpted mRNAs and cloned DNA coding for the two overlapping nonstmctural proteins of influenza vims. Cell 21, 475–485 (1980).
Lamb, R. A., Choppin, P. W.: Identification of a second protein (M2) encoded by RNA segment 7 of influenza vims. Virology 112, 737–745 (1981).
Lamb, R. A., Lai, C.-J.: Conservation of the influenza vims membrane protein (Mj) amino sequence and an open reading frame of RNA segment 7 encoding a second protein (M2) in HNi and H3N2 strains. Virology 112, 746–751 (1981).
Lamb, R. A., Lai, C.-J., Choppin, P. W.: Sequences of mRNAs derived from genome RNA segment 7 of influenza vims: Colinear and interrupted mRNAs code for overlapping proteins. Proc. Nat. Acad. Sci. U.S.A. 78, 4170–4174 (1981).
Laver, W. G., Baker, N.: Amino acid composition of polypeptides from influenza vims particles. J. Gen. Virol. 17, 61–67 (1972).
Lazarowitz, S. G., Choppin, P. W.: Enhancement of the infectivity of influenza A and B vimses by proteolytic cleavage of the hemagglutinin polypeptide. Virology 68, 440–454 (1975).
Lenard, J., Miller, D. K.: PH-dependent hemolysis by influenza, Semliki Porest vims, and Sendai vims. Virology 110, 479–482 (1981).
Lu, B. L., Webster, R. G., Brown, L. E., Nerome, K.: Analysis of antigenic drift in influenza B vimses: do pooled monoclonal antibodies have any utility as a standard reference reagent? Bull. WHO (in press).
Maeda, T., Ohnishi, S.: Activation of influenza vims by acidic media causes hemolysis and fusion of erythrocytes. FEBS Lett. 122, 283–287 (1980).
Markoff, L., Lai, C.-J.: Sequence of the influenza A/Udorn/72 (H3N2) vims neuraminidase gene as determined from cloned full-length DNA. Virology 119, 288–297 (1982).
Martin, M. L., Palmer, E. L., Kendal, A. P.: Lack of characteristic hexagonal surface stmcture on a newly isolated influenza C vims. J. Clinical Micro. 6, 84–86 (1977).
Meier-Ewert, H., Compans, R. W., Bishop, D.H. L., Herrler, G.: Molecular analysis of influenza C vims. In: Negative Strand Vimses and the Host Cell (Mahy, B. W.J., Barry, R. D., eds.), 127–133. New York: Academic Press 1978.
Meier-Ewert, H., Herrler, G., Nagele, A., Compans, R. W.: Glycoproteins of influenza C vims. In: Stmcture and Variation in Influenza Vims (Laver, G., Air, G., eds.). Vol. 5, 357–366. Elsevier/ North-Holland 1980.
Meier-Ewert, H., Nagele, A., Herrler, G., Basak, S., Compans, R. W.: Analysis of influenza C vims stmctural proteins and identification of a virion RNA polymerase. In: Replication of Negative Strand Vimses (Bishop, D.H.L., Compans, R.W., eds.), 173–180. New York: Elsevier 1981a.
Meier-Ewert, H., Petri, T., Bishop, D. H. L.: Oligonucleotide fingerprint analyses of influenza C virion RNA recovered from five different isolates. Arch. Virol. 67, 141–147 (1981b).
Minjou, W., Verhoeyen, M., Devos, R., Saman, E., Fang, R., Huylebroeck, D., Fiers, W., Threlfall, G., Barber, C., Carey, N., Emtage, S.: Complete stmcture of the hemagglutinin gene from the human influenza A/Victoria/3/75 (H3N2) strain as determined from cloned DNA. Cell 19, 686–696 (1980).
Morbidity and Mortality Weekly Report: Follow-up on Reye Syndrome 29, 321–322 (1980a).
Morbidity and Mortality Weekly Report: Reye Syndrome Ohio, Michigan 29, 532–538 (1980b).
Morbidity and Mortality Weekly Report: Influenza Wofldwide 31, 494–495 (1982).
Nagele, A., Meier-Ewert, H.: Submitted for publication, 1983.
Nakamura, K., Compans, R. W.: Glycopeptide components of influenza viral glycoproteins. Virology 86, 432–442 (1978).
Nakamura, K., Compans, R. W.: Biosynthesis of the oligosaccharides of influenza virus glycoproteins. Virology 93, 31–47 (1979).
Nakamura, K., Herrler, G., Petri, T., Meier-Ewert, H., Compans, R. W.: Carbohydrate components of influenza C virions. J. Virol. 29, 997–1005 (1979).
Nelson, D.B., Hurwitz, E.S., Sullivan-Bolyai, J.A., Morens, D.M., Schönberger, L.B.: Reye’s syndrome in the United States in 1977–1978, a non-influenza year. J. Infect. Dis. 140, 436–439 (1979).
Nerome, K., Ishida, M.: The multiphcation of an influenza C virus in an established line of canine kidney (MDCK) cells. J. Gen. Virol. 39, 179–181 (1978).
Nerome, K., Ishida, M., Nakayama, M.: Established cell line sensitive to influenza C virus. J. Gen. Virol. 43, 257–259 (1979).
Norman, M. G., Lowden, J. A., Hill, D. E., Bannatyre, R. M.: Encephalopathy and fatty degeneration of the viscera in childhood. Can. Med. Assoc. J. 99, 549–554 (1968).
O’Callaghan, R.J., Loughlin, S. M., Labat, D. D., Howe, C.: Properties of influenza C virus grown in cell culture. J. Virol. 24, 875–882 (1977).
O’Callaghan, R.J., Gohd, R.S., Labat, D.D.: Human antibody to influenza C virus: Its age-related distribution and distinction from receptor analogs. Infect, and Immun. 30, 500–505 (1980).
Ohuchi, M., Homma, M., Muramatsu, M., Ohyama, S.: Properties of the erythrocyte receptors for influenza C virus. Microbiol. Immunol. 22, 197–203 (1978).
Ohuchi, M., Ohuchi, R., Mifune, K.: Demonstration of hemolytic and fusion activities of influenza C virus. J. Virol. 42, 1076–1079 (1982).
Oxford, S.: Polypeptide composition of influenza B viruses and enzymes associated with the purified virus particles. J. Virol. 12, 827–835 (1973).
Pereira, H.G.: Influenza: antigenic spectrum. Prog. Med. Virol. 11, 46–79 (1969).
Pereira, M. S.: The effect of shifts and drifts on the epidemiology of influenza in man. Phil. Trans. Roy. Soc. (Lond.) B288, 423–432 (1980).
Petri, T, Meier-Ewert, H., Compans, R. W.: Replication and plaque assay of influenza C virus in chicken kidney cells. FEMS Microbiol. Letters 5, 227–230 (1979a).
Petri, T, Meier-Ewert, H., Compans, R.W.: Inhibition of influenza C virus replication by Actinomycin D, a-amanitin, and UV irradiation. J. Virol. 32, 1037–1040 (1979b).
Petri, T, Meier-Ewert, H., Crumpton, W. M., Dimmock, N.J.: RNAs of influenza C virus strains. Arch. Virol. 61, 239–243 (1979c).
Petri, T., Herrler, G., Compans, R. W., Meier-Ewert, H.: Gene products of influenza C virus. FEMS Microbiol. Letters 9, 43–47 (1980).
Pons, M. W., Schulze, I.T., Hirst, G.K.: Isolation and characterization of the ribonucleoprotein of influenza virus. Virology 39, 250–259 (1969).
Portner, A., Webster, R. G., Bean, W. J.: Similar frequencies of antigenic variants in Sendai, vesicular stomatitis, and influenza A viruses. Virology 104, 235–238 (1980).
Racaniello, V. R., Palese, P.: Isolation of influenza C vims recombinants.J. Virol. 32,1006–1014 (1979).
Racaniello, V. R., Palese, P.: Influenza B vims genome: assignment of viral polypeptides to RNA segments. J. Virol. 29, 361–373 (1979).
Rye, R. D. K., Morgan, G., Barol, J.: Encephalopathy and fatty degeneration of the viscera: a disease entity in childhood. Lancet 2, 749–752 (1963).
Ritchey, M. B., Palese, P., Kilbourne, E. D.: RNAs of influenza A, B, and C vimses. J. Virol. 18,738–744 (1976).
Robertson, J. S., Schubert, M., Lazzarini, R. A.: Polyadenylation sites for influenza vims mRNA. J. Virol. 38, 157–163 (1981).
Rodriguez Boulan, E., Sabatini, D.D.: Asymmetric budding of vimses in epithelial monolayers: a model system for study of epithelial polarity. Proc. Nafl. Acad. Sci. U.S.A. 74, 5071–5075 (1978).
Roth, M.G., Fitzpatrick, J. P., Compans, R.W.: Polarity of influenza and vesicular stomatitis vims maturation in MDCK cells: lack of a requirement for glycosylation of viral glycoproteins. Proc. Nafl. Acad. Sci. U.S.A. 76, 6430–6434 (1979)
Scheid, A., Graves, M. C., Silver, S.M., Choppin, P. W.: Studies on the structure and functions of paramyxovirus glycoproteins. In: Negative Strand Vimses and the Host Cell (Mahy, B. W. J., Barry, R.D., eds.), 181–193. London: Academic Press 1978.
Schifif, G.M.: Reye’s syndrome. Ann. Rev. Medicine 27, 447–452 (1976).
Schild, G. C., Pereira, M. S., Chakraverty, P., Coleman, M. T., Dowdle, W. R., Change, W. K.: Antigenic variants of influenza B virus. Brit. Med. J. 4, 127–131 (1973).
Scholtissek, C., Rohde, W., Harms, E.: Genetic relationship between an influenza A and a B virus. J. Gen. Virol. 37, 243–247 (1977).
Schwarz, R. T., Schmidt, M. P. G., Anwer, U., Klenk, H.-D.: Carbohydrates of influenza vims. 1. Glycopeptides derived from viral glycoproteins after labeling with radioactive sugars. J. Virol. 23, 217–226 (1977).
Shaw, M.W., Lamb, R.A., Erickson, B.W., Briedis, D.J., Choppin, P.W.: Complete nucleotide sequence of the neuraminidase gene of influenza B vims. Proc. Natl. Acad. Sci. 79, 6817–6821 (1982).
Skehel, J., Hay, A.J.: Nucleotide sequences at the 5’ termini of influenza virus RNAs and their transcripts. Nucleic Acids Res. 5, 1207–1219 (1978).
Stuart-Harris, C.H., Schild, G.C.: In: Influenza: The Vimses and the Disease, 22–27. London: Edward Arnold 1976.
Sugawara, K., Ohuchi, M., Nakamura, K., Homma, M.: Effects of various proteases on the glycoprotein composition and the infectivity of influenza C vims. Arch. Virol. 68, 147–151 (1981).
Tobita, K., Kilbourne, E. D.: Genetic recombination for antigenic markers of antigenically different strains of influenza B vims. J. Virol. 13, 347–352 (1974).
Ueda, M., Tobita, A., Suguira, A., Enomoto, C.: Identification ofhemagglutinin and neuraminidase genes of influenza B vims. J. Virol. 25, 685–686 (1978).
Verhoeyen, M., Fang, R., Minjou, W., Devos, R., Huylebroeck, D., Saman, E., Fiers, W.: Antigenic drift between the hemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75. Nature (Lond.) 286, 771–776 (1980).
Ward, C. W.: Stmcture of the influenza virus hemagglutinin. Curr. Topics Microbiol, and Immunol. 94/95, 1–74 (1981).
Waterfield, M. D., Espehe, K., Skehel, J. J.: Stmcture of the hemagglutinin of influenza vims. Br. Med. Bull. 35, 57–63 (1979).
Waterson, A. P., Hurrell, J. M. W., Jensen, K. E.: The fine stmcture of influenza A, B, and C vimses. Arch. ges. Virusforsch. 12, 487–495 (1963).
Webster, R. G., Berton, M. T: Analysis of antigenic drift in the hemagglutinin molecule of influenza B vimses with monoclonal antibodies. J. Gen. Virol. 54, 243–251 (1981).
Webster, R. G., Hinshaw, V. S.: Matrix protein from influenza A vims and its role in cross-protection in mice. Infect. Immun. 17, 561–566 (1977).
Webster, R. G., Laver, W. G.: Antigenic variation of influenza viruses. In: The Influenza Vimses and Influenza (Kilbourne, E.D., ed.), 269–314. New York: Academic Press 1975.
Wilson, LA., Skehel, J. J., Wiley, D.C.: Stmcture of the hemagglutinin membrane glycoprotein of influenza vims at 3 A resolution. Nature (Lond.) 289, 366–373 (1981).
Winter, G., Fields, S.: Cloning of influenza DNA into M13: The sequence of the RNA segment encoding the A/PR/8/34 matrix protein. Nucleic Acids Res. 8, 1965–1974 (1980).
Winter, G., Fields, S., Brownlee, G. G.: Nucleotide sequence of the hemagglutinin gene of a human influenza virus HI subtype. Nature (Lond.) 292, 72–75 (1981).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag/Wien
About this chapter
Cite this chapter
Air, G.M., Compans, R.W. (1983). Influenza B and Influenza C Viruses. In: Palese, P., Kingsbury, D.W. (eds) Genetics of Influenza Viruses. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8706-7_9
Download citation
DOI: https://doi.org/10.1007/978-3-7091-8706-7_9
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-8708-1
Online ISBN: 978-3-7091-8706-7
eBook Packages: Springer Book Archive