Concentration in the Aqueous of Various Sulphonamides After Systemic Administration
The earlier experimental studies of Bellows and Chinn (1939 and 1941), Pinkoff (1939), Meyer, Bloch and Chamberlain (1941), Liebman and Newman (1941), and Scheie and Souders (1941), have established that sulphanilamide and sulphapyridine penetrate readily into the interior of the eye on oral administration, whilst sulphathiazole has a poor penetration. The penetration of sulphadiazine was found to be high (Scheie and Souders, 1941; Liebman and Newman, 1941). There do not appear to be any studies on the newer sulphonamides such as sulphamezathine and sulphamerazine. For clinical purposes sulphanilamide and sulphapyridine can be ignored as they are no longer widely used owing to their relative toxicity. In practice the choice to-day is largely limited to sulphadiazine, sulphamerazine, sulphamezathine and sulphathiazole. The present study was undertaken to assess the relative penetration of these sulphonamides into the aqueous.
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- Pinkoff (1939).—Ophthalmologica, 97, 357.Google Scholar