Studies on the Intra-Ocular Fluids
Experiments on the rate of penetration of sugars (Duke-Elder and Davson, 1949) and salts (Duke-Elder, Davson and Maurice, 1949) from the blood into the intra-ocular fluids reported earlier in this series have revealed a selectivity in the barrier separating these fluids, inconsistent with the conception of penetration through a simple pore-structure such as would be provided by the intercellular spaces of an endothelial or epithelial membrane. We were forced to conclude, on the basis of these studies, that the penetration of many substances into the intra-ocular fluids represented a transcellular process since it is only in the membranes of cells that we can expect to find a selectivity of the type described (Davson and Danielli, 1942). Experiments on the penetration of some amino-compounds—creatinine, urea, glycine, and alanine—to be described here, support this view. The above-named compounds have the following molecular weights:—
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