A Neuropharmacological Investigation on Hallucinogenic Drugs. Laboratory Results versus Clinical Trials

  • V. G. Longo
  • D. Bovet


Since 1947, when the peculiar effects of lysergic acid diethylamide (LSD) on psychic functions were first described (Stoll) interest in this substance both in purely scientific and clinical circles has steadily increased. The psychological disturbances provoked in man by LSD are rather specific even though they are to some extent similar to those observed with alcohol, cocaine, or marihuana and, even more so, to those of mescaline or psylocibin. In fact, the disturbances of perception, the visual hallucinations, the sense of depersonalization, and in some instances a certain clouding of consciousness, are produced by extremely minute doses (0.001 mg./kg.), and the pronounced psychic manifestations are observed with relatively slight secondary effects or alterations of other systems.


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Copyright information

© Springer-Verlag Wien 1964

Authors and Affiliations

  • V. G. Longo
    • 1
  • D. Bovet
    • 1
  1. 1.Istituto Superiore di SanitàRomeItaly

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