Although clinically recognized acute hepatitis, a generalized infection with inflammation of liver in epidemics, had been known since the time of Hippocrates, it was only after the development of specific serologic tests for the markers of hepatitis A virus (HAV) that it has been possible to obtain a differentiation of HAV cases with certainty from those caused by hepatitis B virus (HBV) and hepatitis C virus (HCV) or hepatitis E virus (HEV) (non-A, non-B hepatitis) (Tabor, 1984). Serologic test has enabled the recognition of asymptomatic cases of HAV infection and the symptoms characteristic of serologie specific hepatitis A. Various clinical aspects of hepatitis A virus infection are discussed in this chapter.
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