Diagnosis of hepatitis C and hepatitis E virus infections
The term non-A, non-B hepatitis was initially applied as a diagnosis to patients whose viral hepatitis, after other causes had been excluded, seemed to have been acquired by the blood-borne route. Currently, two epidemiologically distinct types of non-A, non-B hepatitis (NANBH) have been identified worldwide and are believed to be probably caused by different viruses. One type is transmitted parenterally and is associated with acute hepatitis that develops after transfusion and sporadic cases occurring primarily in developed countries. The other type is transmitted by the fecal-oral route and is primarily associated with epidemic cases of acute hepatitis in developing countries. The characteristics of both types of NANB hepatitis are essentially indistinguishable but the chronic consequences however, appear to be markedly different.
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