Studies on the Control of Pineal Indole Synthesis: Cyclic Nucleotides, Adenylate Cyclase and Phosphodiesterase
An overview of the biochemical events that occur when postsynaptic pineal beta-adrenergic receptors are stimulated is presented. Emphasis is placed on the importance of the adenylate cyclase system for the induction of N-acetyltransferase (NAT). Super- and subsensitive responses of NAT to receptor agonists are related to cAMP concentration, adenylate cyclase and Phosphodiesterase activities and receptor binding sites.
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