Studies on the Control of Pineal Indole Synthesis: Cyclic Nucleotides, Adenylate Cyclase and Phosphodiesterase

  • M. A. Oleshansky
  • N. H. Neff
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 13)


An overview of the biochemical events that occur when postsynaptic pineal beta-adrenergic receptors are stimulated is presented. Emphasis is placed on the importance of the adenylate cyclase system for the induction of N-acetyltransferase (NAT). Super- and subsensitive responses of NAT to receptor agonists are related to cAMP concentration, adenylate cyclase and Phosphodiesterase activities and receptor binding sites.


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Copyright information

© Springer-Verlag Wien 1978

Authors and Affiliations

  • M. A. Oleshansky
    • 1
  • N. H. Neff
    • 2
  1. 1.Neuropsychopharmacology Research Unit, Department of PsychiatryNew York University Medical CenterNew York CityUSA
  2. 2.Laboratory of Preclinical PharmacologyNational Institute of Mental Health, St. Elizabeths HospitalWashington, D.C.USA

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