Melatonin: Clinical Pharmacology

  • A. B. Lerner
  • J. J. Nordlund
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 13)


The use and metabolic fate of melatonin and related compounds in mammals are reviewed.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Altschule, M. D.: Personal communication (1968).Google Scholar
  2. Anton-Tay, F., Diaz, J. L., Fernandex-Guardiola, A.: On the Effect of Melatonin upon Human Brain: Its possible Therapeutic Implications. Life Sci. 10, 841–850 (1971).CrossRefGoogle Scholar
  3. Burns, J. K.: Administration of Melatonin to Non-human Primates and to Women with Breast Carcinoma. J. Physiol. 229, 38–39 (1973).Google Scholar
  4. Carman, J. S., Post, R. M., Buswell, R., Goodwin, F. K.: Negative Effects of Melatonin on Depression. Am. J. Psychiatry 133, 1181–1186 (1976).CrossRefPubMedGoogle Scholar
  5. Challis, J. R. G., Torosis, J. D.: Is α-MSH a trophic hormone to adrenal function in the fetus? Nature 269, 818–819 (1977).CrossRefPubMedGoogle Scholar
  6. Coleman, M.: Personal communication to the author (1977).Google Scholar
  7. Cotzias, G. C., Papavasiliou, P. S., Ginos, J., et al.: Metabolic modification of Parkinson’s disease and of Chronic Managanese Poisoning. Annual Rev. Med. 22, 305–326 (1971).CrossRefGoogle Scholar
  8. Cramer, H., Rudolph, J., Consbruch, U., Rendei, K.: On the Effects of Melatonin on Sleep and Behavior in Man. Adv. in Biochem. Psychopharm. 11, 187–191 (1974).Google Scholar
  9. Fanello, R. G., Bubenik, G. A., Brown, G. M., Grota, L. J.: Epileptogenic Action of Intraventricularly Injected Antimelatonin Antibody. Neurology 27, 567–570 (1977).CrossRefGoogle Scholar
  10. Fideleff, H., Aparicio, N. J., Guitelman, A., Debeljuk, L., Mancini, A., Cramer, C.: Effect of Melatonin on the Basal and Stimulated Gonadotropin Levels in Normal Men and Postmenopausal Women. J. Clin. Endocrinol. and Metab. 42, 1014–1017 (1976).CrossRefGoogle Scholar
  11. Hartmann, E., Cravens, J., List, S.: Hypnotic Effects of Tryptophan. Arch. Gen. Psy. 31, 394–397 (1974).CrossRefGoogle Scholar
  12. Hirata, F., Hayaishi, O., Tokuyama, T., Senoh, S.: In vitro and in vivo Formation of Two New Metabolites of Melatonin. J. Biol. Chem. 249, 1311–1313 (1974).PubMedGoogle Scholar
  13. Kline, N.: Personal communication to the author (1977).Google Scholar
  14. Kopin, I. J., Pare, C. M. B., Axelrod, J., Weissbach, H.: The Fate of Melatonin in Animals. J. Biol. Chem. 236, 3072–3075 (1961).PubMedGoogle Scholar
  15. Lerner, A. B., Case, J. D.: Melatonin. Fed. Proc. 19, 590–592 (1960).Google Scholar
  16. Lieberman, A. D.: Personal communication (1971).Google Scholar
  17. Lynch, H. J., Wurtman, R. J., Moskowitz, M. A., et al.: Daily Rhythm in Human Urinary Melatonin. Sci. 187, 169–171 (1975).CrossRefGoogle Scholar
  18. McIsaac, M. W., Farrell, G., Taborsky, R. G., Taylor, A.: Indole Compounds: Isolation from Pineal Tissue. Sci. 148, 102–103 (1965).CrossRefGoogle Scholar
  19. Nordlund, J. J., Lerner, A. B.: Unpublished data.Google Scholar
  20. Nordlund, J. J., Lerner, A. B.: Melatonin: Its Effect on Skin Color, Pituitary Trophic Hormones and its Toxicity in Human Subjects. J. Clin. Endocrinol. and Metabol. 45, 152–158 (1977).CrossRefGoogle Scholar
  21. Papavasiliou, P. S., Cotzias, G. C., Duby, S. E., et al.: Melatonin and Parkinsonism. JAMA 221, 88 (1972).CrossRefPubMedGoogle Scholar
  22. Shaw, K. M., Stern, G. M., Sandler, M.: Melatonin and Parkinsonism. Lancet (London) 1, 271 (1973).CrossRefGoogle Scholar
  23. Smythe, G. A., Lazarus, L.: Growth Hormone Responses to Melatonin in Man. Sci. 184, 1373–1374 (1974).CrossRefGoogle Scholar
  24. Starr, K. W.: Growth and New Growth: Environmental Carcinogens in the Process of Human Ontogeny. In: Progr. Clin. Cancer 4 (Ariel, I. L., ed.), pp. 1–29. New York: Grune and Stratton. 1970.Google Scholar
  25. Swaab, D. F., Wissen, M., Tilders, F. J.: Stimulation of Intra-Uterine Growth in Rat by Alpha-Melanocyte Stimulating Hormone. J. Endocrinol. 70, 445–455 (1976).CrossRefPubMedGoogle Scholar
  26. Van Woert, M. H., Cotzias, G. C.: Personal communication (1969).Google Scholar
  27. Wetterberg, L.: Melatonin in Serum. Nature 269, 646 (1977).CrossRefPubMedGoogle Scholar
  28. Wilson, B. W., Snedden, W., Silman, R. E., Smith, I., Mullens, P.: A Gas Chromatography-Mass Spectrometry Method for the Quantitative Analysis of Melatonin in Plasma and Cerebrospinal Fluid. Anal. Biochem. 81, 283–291 (1977).CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 1978

Authors and Affiliations

  • A. B. Lerner
    • 1
  • J. J. Nordlund
    • 1
  1. 1.Department of DermatologyYale University School of MedicineNew HavenUSA

Personalised recommendations