Physiological Effects of Melatonin
The first report suggesting that melatonin had physiological effects in any vertebrate were probably those of Lerner’s laboratory, in 1958, showing that this indole caused the melanophores in certain amphibians to blanch (Lerner et al., 1958). It is perhaps curious that almost two decades later, really compelling evidence that melatonin normally affects pigmentation is still lacking. (Nordlund and Lerner have noted a decrease in pigmentation in a single patient with Adrenogenital Syndrome given 1 gram of melatonin per day orally, for 30 days; no change was noted in any of four patients with idiopathic hyperpigmentation.
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