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Calmodulin, Ca2+-Antagonists and Ca2+-Transporters in Nerve and Muscle

  • J. D. Johnson
  • Laura A. Wittenauer
  • R. D. Nathan
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 18)

Summary

Calcium is of fundamental importance in the regulation of both muscle contraction and neurosecretion. Its control of these processes is achieved by its binding and activation of various Ca2+-binding proteins (CBP), including those in the Ca2+ channel, the Na+-Ca2+ antiporter, and intracellular calmodulin (CDR). Generally, Ca2+-binding to regulatory CBP exposes hydrophobic sites on their surface at which the CBP interfaces with its receptor or binds inhibitory hydrophobic ligands. We find that some Ca2+-antagonist drugs (Ca-ANT) bind to and inhibit calmodulin and that some calmodulin antagonists (CDR-ANT) block Ca2+ channels. This suggests that CDR and the CBP that regulate the Ca2+ channel may be quite homologous proteins. Ca-ANT and CDR-ANT are not effective inhibitors of the Na+-Ca2+ antiporters of heart sarcolemma and brain synaptosomes, suggesting that these antiporters are fundamentally different from the antiporter of heart mitochondria. These results are discussed in terms of Ca2+-binding proteins being potential targets for pharmacological interventions designed to block specific aspects of the action of calcium.

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Copyright information

© Springer-Verlag Wien 1983

Authors and Affiliations

  • J. D. Johnson
    • 1
    • 3
  • Laura A. Wittenauer
    • 1
  • R. D. Nathan
    • 2
  1. 1.Department of Pharmacology and Cell BiophysicsUniversity of Cincinnati College of MedicineCincinnatiUSA
  2. 2.Department of PhysiologyTexas Tech University Health Sciences CenterLubbockUSA
  3. 3.Department of Pharmacology and Cell BiophysicsUniversity of Cincinnati College of MedicineCincinnatiUSA

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