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(3,4-Dihydroxyphenylimino)-2-Imidazoline (DPI) and Its Action at Noradrenergic and Dopaminergic Receptors in the Nucleus Accumbens of Rats: Mesolimbic Catecholamine Receptors and Hyperactivity

  • A. R. Cools
  • S. K. Oosterloo
Conference paper
Part of the Journal of Neural Transmission book series (NEURAL SUPPL, volume 18)

Summary

Bilateral administration of ergometrine into the nucleus accumbens of rats pretreated 1–3 min earlier with intra-accumbens injections of noradrenaline, phenylephrine, clonidine and phentolamine has been found to produce a normal ergometrine-induced hyperactivity. In contrast, low doses of dopamine and (3,4-dihydroxyphenylimino)-2-imidazoline (DPI) and only high doses of clonidine and phentolamine have been found to attenuate the ergometrine response. These data together with the finding that phentolamine is unable to alter DPI’s ability to suppress the ergometrine response provide direct evidence that the latter DPI effect is certainly not due to its ability to act as an agonist at α-NE receptors within the nucleus accumbens of rats.

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Copyright information

© Springer-Verlag Wien 1983

Authors and Affiliations

  • A. R. Cools
    • 1
  • S. K. Oosterloo
    • 2
  1. 1.Department of PharmacologyUniversity of NijmegenNijmegenThe Netherlands
  2. 2.Department of PharmacologyUniversity of NijmegenNijmegenThe Netherlands

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