Vascular Disorders: Vasculitis

  • Serge Weis
  • Michael Sonnberger
  • Andreas Dunzinger
  • Eva Voglmayr
  • Martin Aichholzer
  • Raimund Kleiser
  • Peter Strasser


Vasculitis is an inflammation of blood vessel walls due to infectious or non-infectious reasons. The size of the vessel serves for disease classification (e.g., large vessel vasculitis, medium vessel vasculitis, small vessel vasculitis). The morphological changes of the involved vessels might be variable. The pathogenesis of non-infectious vasculitis might be autoimmune, associated with an immunologic reaction directed at elastin, associated with human leukocyte antigen (HLA)-B∗51 (Behçet’s disease), associated with immune and inflammatory response, antineutrophil cytoplasmic antibody-associated vasculitides. Germ line mutations lead to adenosine deaminase 2 deficiency.

Treatment in infectious vasculitis uses antiviral and antibacterial agents, while in non-infectious vasculitis corticosteroids and immune suppressants (cyclophosphamide, methotrexate, azathioprine) are used. Clinical outcome depends on the involvement of other organs and pre-existing illnesses.

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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • Serge Weis
    • 1
  • Michael Sonnberger
    • 2
  • Andreas Dunzinger
    • 3
  • Eva Voglmayr
    • 2
  • Martin Aichholzer
    • 4
  • Raimund Kleiser
    • 2
  • Peter Strasser
    • 5
  1. 1.Division of Neuropathology, Neuromed CampusKepler University Hospital, Johannes Kepler UniversityLinzAustria
  2. 2.Department of Neuroradiology, Neuromed CampusKepler University Hospital, Johannes Kepler UniversityLinzAustria
  3. 3.Department of Neuro-Nuclear Medicine, Neuromed CampusKepler University Hospital, Johannes Kepler UniversityLinzAustria
  4. 4.Department of Neurosurgery, Neuromed CampusKepler University Hospital, Johannes Kepler UniversityLinzAustria
  5. 5.PMU University Institute for Medical & Chemical Laboratory DiagnosticsSalzburgAustria

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