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Future vaccines against emerging encephalitides

  • Robert E. Johnston
  • N. L. Davis
Chapter
  • 182 Downloads
Part of the Archives of Virology. Supplementa book series (ARCHIVES SUPPL, volume 18)

Summary

The vaccine strategies available for control of emerging encephalitides range in a continuum from traditional approaches to those utilizing new technologies. In this report, we explore the use of live attenuated vaccines where the attenuating mutations have been selected in a rational way to improve attenuation without sacrificing effectiveness. A strategy for paired lethal and resuscitating mutations is presented that will greatly reduce the possibility of reversion to virulence. Finally, we describe an example of a vaccine vector system that could be rapidly adapted for use against these virus diseases as they emerge.

Keywords

Drain Lymph Node Sindbis Virus Baby Hamster Kidney Cell Venezuelan Equine Encephalitis Virus Equine Arteritis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 2004

Authors and Affiliations

  • Robert E. Johnston
    • 1
  • N. L. Davis
    • 1
  1. 1.Carolina Vaccine InstituteUniversity of North CarolinaChapel HillNorth CarolinaUSA

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