Advertisement

Zusammenfassung

Antacida sind in der Therapie des Ulcus duodeni (UD) auch in niedriger Dosierung effektiv einsetzbar. Sie sind in der Schubtherapie des UD ebenso wirksam wie Cimetidin, Ranitidin und Misoprostol.

In der Langzeittherapie wurden Antacida in niedriger Dosierung ebenfalls erfolgreich als Therapeutika zur Rezidivprophylaxe des UD eingesetzt und zeigten eine den H2-Blockern gleichwertige Effektivität.

Da die verwendeten effektiven Dosierungen der Antacida bei der beschleunigten Abheilung des UD im Vergleich zu Plazebo und/oder H2-Blockern mit Sicherheit nur minimale pH-Wertänderungen im Magen und Duodenum bewirken, muß angenommen werden, daß der effektive Therapieeffekt der Antacida beim UD nicht allein durch die Säureneutralisation zu erklären ist.

Antacid therapy in duodenal ulcer disease

Abstract

Even in low doses antacids are effective in the treatment of duodenal ulcer. In the treatment of acute duodenal ulcer they are equally effective as cimetidine, ranitidine or misoprostol. In long-term therapy, antacids have proved equally successful in low doses as prophylactics against a recurrence of duodenal ulcer, and were just as effective as H2-blockers. Since the doses of antacids required to accelerate the healing of a duodenal ulcer result in only minimal changes in gastric and duodenal pH, it must be assumed that the therapeutic effect of antacids is not only a function of acid neutralization.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literaturverzeichnis

  1. 1.
    Bardhan KD. Are antacids as effective as cimetidine in preventing duodenal ulcer relapse? A multicenter study. Gastroenterology 1986; 90: 1336.Google Scholar
  2. 2.
    Bardhan KD, Hunter JO , Miller JP et al. Antacid maintenance treatment in the prevention of duodenal ulcer relapse. Gut 1988; 29: 1748–1754.PubMedCentralCrossRefPubMedGoogle Scholar
  3. 3.
    Becker U, Lindorff K, Andersen C, Ranlov PJ. Antacid treatment of duodenal ulcer. Acta Med Scand 1987; 221: 95–101.CrossRefPubMedGoogle Scholar
  4. 4.
    Berstad A, Rydning A, Aadland E, Kolstad B, Frislid K, Aaseth J. Controlled clinical trial of duodenal ulcer healing with antacid tablets. Scand J Gastroenterol 1982; 17: 953–959.CrossRefPubMedGoogle Scholar
  5. 5.
    Berstad A, Weberg R. Antacids in the treatment of gastroduodenal ulcer. Scand J Gastroenterol 1986; 21: 385–391.CrossRefPubMedGoogle Scholar
  6. 6.
    Bianchi Porro G, Lazzaroni M, Pace F, Petrillo M. Longterm low-dose antacid versus cimetidine therapy in the treatment of duodenal ulcer recurrence. Scand J Gastroenterol 1986; 21: 1144–1146.CrossRefGoogle Scholar
  7. 7.
    Bianchi Porro G, Parente F, Lazzaroni M, Baronl S, Panza E. Medium-dose antacids versus cimetidine in the short-term treatment of duodenal ulcer. J Clin Gastroenterol 1986; 8: 141–145.CrossRefGoogle Scholar
  8. 8.
    Burget DW, Chiverton SG, Hunt RH. Is there an optimal degree of acid suppression for healing of duodenal ulcers? A model of the relationship between ulcer healing and acid suppression. Gastroenterology 1990; 99: 345–351.PubMedGoogle Scholar
  9. 9.
    Caspary WF, Hengels KJ, Kunert H et al. Low-dose antacid therapy in the treatment of duodenal ulcer — a multicentre double-blind trial vs. misoprostol. Z Gastroenterol 1991; 29: 411–416.PubMedGoogle Scholar
  10. 10.
    Crohn BB, Rosenak BD. An exhibition of books shown at the graduate fortnight illustrating the progress in gastroenterology. Bul NY Acad Med 1935; 1 1: 74.Google Scholar
  11. 11.
    Dijoseph JF, Borella LE, Mir GN. Activated aluminium complex derived from solubilized antacids exhibits enhanced cytoprotective activity in the rat. Gastroenterology 1989; 96: 730–735.PubMedGoogle Scholar
  12. 12.
    Dijoseph JF, Borella LE, Wells CL, Mir GN. Mucosal protective activity of activated aluminum complex. Digestion 1990: 45: 19–25.CrossRefPubMedGoogle Scholar
  13. 13.
    Faizallah R, DE Haan HA, Krasner N et al. Is there a place in the United Kingdom for intensive antacid treatment for chronic peptic ulceration? Br Med J 1984; 289: 869–871.CrossRefGoogle Scholar
  14. 14.
    Fedeli G, Anti M, Rapaccini GL, de Vitis I, Butti A, Civello IM. A controlled study comparing cimetidine treatment to an intensive antacid regimen in the therapy of uncomplicated duodenal ulcer. Dig Dis Sci 1979; 24: 758–762.CrossRefPubMedGoogle Scholar
  15. 15.
    Hunter JO, Walker RJ, Crowe J et al. Double-blind randomized multicenter study comparing Maalox TC tablets and ranitidine in healing duodenal ulcers. Dig Dis Sci 1991; 36: 911–916.CrossRefPubMedGoogle Scholar
  16. 16.
    Ippoliti AF, Sturdevant Ral, Isenberg JI et al. Cimetidine versus intensive antacid therapy for duodenal ulcer: a multicenter trial. Gastroenterology 1978; 74: 393–395.PubMedGoogle Scholar
  17. 17.
    Kumar N, Vij JC, Karol A, Anand BS. Controlled therapeutic trial to determine the optimal dose of antacids in duodenal ulcer. Gut 1984; 25: 1199–1202.PubMedCentralCrossRefPubMedGoogle Scholar
  18. 18.
    Lam SK, Antacids: the past, the present and the future. Baillière’s Clin Gastroenterol 1988; 2: 641–654.CrossRefGoogle Scholar
  19. 19.
    Lam SK, Lam KC, Lai CL, Yeung CK, Yam LYC, Wong WS. Treatment of peptic ulcer with antacid and sulpiride: a double-blind controlled study. Gastroenterology 1979; 76: 315–322.PubMedGoogle Scholar
  20. 20.
    Lauritsen K, Bytzer P, Hansen J, Bekker C, Rask-Madsen J. Comparison of ranitidine and high-dose antacid in the treatment of prepyloric and duodenal ulcer: a doubleblind controlled trial. Scand J Gastroenterol 1985; 20: 123–128.CrossRefPubMedGoogle Scholar
  21. 21.
    Lux G, Hentschel H, Rohner HG et al. Treatment of duodenal ulcer with low-dose antacids. Scand J Gastroenterol 1986; 21: 1063–1068.CrossRefPubMedGoogle Scholar
  22. 22.
    Miller JP. Maintenance of duodenal ulcer healing by antacids. Scand J Gastroenterol 1990; 25 (Suppl 174): 54–59.CrossRefGoogle Scholar
  23. 23.
    Peterson WL, Sturdevant Ral, Frankl HD et al. Healing of duodenal ulcer with an antacid regimen. N Engl J Med 1977; 297: 341–345.CrossRefPubMedGoogle Scholar
  24. 24.
    Weberg R, Berstad A, Lange O, Schultz T, Aubert E. Duodenal ulcer healing with four antacid tablets daily. Scand J Gastroenterol 1985; 20: 1041–1045.CrossRefPubMedGoogle Scholar
  25. 25.
    Zaterka S, Cordeiro F, Lyra LGC et al. Very-low dose antacid in treatment of duodenal ulcer. Comparison with cimetidine. Dig Dis Sci 1991; 36: 1383.CrossRefGoogle Scholar

Copyright information

© Springer Fachmedien Wiesbaden 1992

Authors and Affiliations

  • W. F. Caspary
    • 1
  1. 1.Zentrum der Innere Medizin, Abteilung GastroenterologieUniversitätsklinikum FrankfurtDeutschland

Personalised recommendations