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Wenn das Zusammenspiel der Gedächtnisse nicht klappt

  • Rainer H. StraubEmail author
Chapter

Zusammenfassung

Die vorausgehenden Buchteile I und II machten deutlich, wie ein einziges Gedächtnis und das Zusammenspiel von verschiedenen Gedächtnissen unter gesunden Bedingungen funktionieren. In den drei vorausgehenden Kapiteln wurden Gedächtnisstörungen und jeweilige Krankheitskonsequenzen in den drei verschiedenen Bereichen „mental“, „immunologisch“ und „energiespeichernd“ isoliert dargestellt. Hier werden nun Krankheiten beispielhaft vorgestellt, bei denen die Verknüpfungsbahnen oder Verbindungen zwischen den Gedächtnissen krankheitsfördernde Bedeutung bekommen. Betrachten Sie es als Plädoyer für eine umfassendere Betrachtung des Patienten, eine umfänglichere Therapie und die Interdisziplinarität der Ärzte und medizinischen Wissenschaftler.

Literatur

  1. Aceves-Avila FJ, Medina F, Fraga A (2001) The antiquity of rheumatoid arthritis: a reappraisal. J Rheumatol 28(4):751–757Google Scholar
  2. Andersson KME, Wasen C, Juzokaite L, Leifsdottir L, Erlandsson MC, Silfversward ST et al (2018) Inflammation in the hippocampus affects IGF1 receptor signaling and contributes to neurological sequelae in rheumatoid arthritis. Proc Natl Acad Sci U S A. 115(51):E12063–E12072CrossRefGoogle Scholar
  3. Arner P, Bernard S, Appelsved L, Fu KY, Andersson DP, Salehpour M, Thorell A, Rydén M, Spalding KL (2019) Adipose lipid turnover and long-term changes in body weight. Nat Med 25(9):1385–1389 Google Scholar
  4. Avgerinos KI, Kalaitzidis G, Malli A, Kalaitzoglou D, Myserlis PG, Lioutas VA (2018) Intranasal insulin in Alzheimer’s dementia or mild cognitive impairment: a systematic review. J Neurol 265(7):1497–1510CrossRefGoogle Scholar
  5. Barker DJ (2007) Obesity and early life. Obes Rev 8(Suppl 1):45–49CrossRefGoogle Scholar
  6. Bedse G, Di Domenico F, Serviddio G, Cassano T (2015) Aberrant insulin signaling in Alzheimer’s disease: current knowledge. Front Neurosci. 9:204CrossRefGoogle Scholar
  7. Boney CM, Verma A, Tucker R, Vohr BR (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115(3):e290–e296CrossRefGoogle Scholar
  8. Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A et al (2017) Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature 550(7674):119–123CrossRefGoogle Scholar
  9. Cao L, Choi EY, Liu X, Martin A, Wang C, Xu X et al (2011) White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis. Cell Metab 14(3):324–338CrossRefGoogle Scholar
  10. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB et al (2009) Identification and importance of brown adipose tissue in adult humans. N Engl J Med 360(15):1509–1517CrossRefGoogle Scholar
  11. Deuschl G, Maier W. S. 3-Leitlinie Demenzen. 2016. Leitlinien für Diagnostik und Therapie in der Neurologie. www.dgn.org/leitlinien
  12. Dhurandhar NV, Bailey D, Thomas D (2015) Interaction of obesity and infections. Obes Rev 16(12):1017–1029CrossRefGoogle Scholar
  13. Domen RE (1981) Peleopathological evidence of rheumatoid arthritis. JAMA 246(17):1899CrossRefGoogle Scholar
  14. Dreßing H (2016) Kriterien bei der Begutachtung der posttraumatischen Belastungsstörung. Hessisches Ärzteblatt. 77(5):271–275Google Scholar
  15. Elzinga BM, Bremner JD (2002) Are the neural substrates of memory the final common pathway in posttraumatic stress disorder (PTSD)? J Affect Disord 70(1):1–17CrossRefGoogle Scholar
  16. Eriksson JG, Forsen T, Tuomilehto J, Osmond C, Barker DJ (2003) Early adiposity rebound in childhood and risk of type 2 diabetes in adult life. Diabetologia 46(2):190–194CrossRefGoogle Scholar
  17. Fenster RJ, Lebois LAM, Ressler KJ, Suh J (2018) Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man. Nat Rev Neurosci 19(9):535–551CrossRefGoogle Scholar
  18. Glaesmer H, Brahler E, Gundel H, Riedel-Heller SG (2011) The association of traumatic experiences and posttraumatic stress disorder with physical morbidity in old age: a German population-based study. Psychosom Med 73(5):401–406CrossRefGoogle Scholar
  19. Goto T, Naknukool S, Yoshitake R, Hanafusa Y, Tokiwa S, Li Y et al (2016) Proinflammatory cytokine interleukin-1beta suppresses cold-induced thermogenesis in adipocytes. Cytokine 77:107–114CrossRefGoogle Scholar
  20. Hainer V, Zamrazilova H, Kunesova M, Bendlova B, Aldhoon-Hainerova I (2015) Obesity and infection: reciprocal causality. Physiol Res 64(Suppl 2):S105–S119Google Scholar
  21. Hensvold AH, Magnusson PK, Joshua V, Hansson M, Israelsson L, Ferreira R et al (2015) Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins. Ann Rheum Dis 74(2):375–380CrossRefGoogle Scholar
  22. Hiepe F, Dorner T, Hauser AE, Hoyer BF, Mei H, Radbruch A (2011) Long-lived autoreactive plasma cells drive persistent autoimmune inflammation. Nat Rev Rheumatol 7(3):170–178CrossRefGoogle Scholar
  23. Hilmes O (2013) Ludwig II – Der Unzeitgemäße König. Siedler Verlag, MünchenGoogle Scholar
  24. Jacobs HI, Radua J, Luckmann HC, Sack AT (2013) Meta-analysis of functional network alterations in Alzheimer’s disease: toward a network biomarker. Neurosci Biobehav Rev 37(5):753–765CrossRefGoogle Scholar
  25. Jenei-Lanzl Z, Zwingenberg J, Lowin T, Anders S, Straub RH (2015) Proinflammatory receptor switch from Galphas to Galphai signaling by beta-arrestin-mediated PDE4 recruitment in mixed RA synovial cells. Brain Behav Immun 50:266–274CrossRefGoogle Scholar
  26. Jones ME, Lebonville CL, Barrus D, Lysle DT (2015) The role of brain interleukin-1 in stress-enhanced fear learning. Neuropsychopharmacology 40(5):1289–1296CrossRefGoogle Scholar
  27. Klareskog L, Catrina AI (2015) Autoimmunity: lungs and citrullination. Nat Rev Rheumatol 11(5):261–262CrossRefGoogle Scholar
  28. Kurochkin IV, Goto S (1994) Alzheimer’s beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme. FEBS Lett 345(1):33–37CrossRefGoogle Scholar
  29. Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR et al (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538):197–206CrossRefGoogle Scholar
  30. Luo S, Romero A, Adam TC, Hu HH, Monterosso J, Page KA (2013) Abdominal fat is associated with a greater brain reward response to high-calorie food cues in Hispanic women. Obesity (Silver Spring) 21(10):2029–2036CrossRefGoogle Scholar
  31. Meade T, Manolios N, Cumming SR, Conaghan PG, Katz P (2018) Cognitive impairment in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken) 70(1):39–52CrossRefGoogle Scholar
  32. Mellon SH, Gautam A, Hammamieh R, Jett M, Wolkowitz OM (2018) Metabolism, metabolomics, and inflammation in posttraumatic stress disorder. Biol Psychiatr 83(10):866–875CrossRefGoogle Scholar
  33. Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ et al (2012) Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71(5):362–381CrossRefGoogle Scholar
  34. Ozer EJ, Best SR, Lipsey TL, Weiss DS (2003) Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis. Psychol Bull 129(1):52–73CrossRefGoogle Scholar
  35. Peng X, Zhang Q, Liao C, Han W, Xu F (2018) Epigenomic control of thermogenic adipocyte differentiation and function. Int J Mol Sci 19(6):1793Google Scholar
  36. Pongratz G, Straub RH (2014) The sympathetic nervous response in inflammation. Arthritis Res Ther 16(6):504CrossRefGoogle Scholar
  37. Raffaitin C, Gin H, Empana JP, Helmer C, Berr C, Tzourio C et al (2009) Metabolic syndrome and risk for incident Alzheimer’s disease or vascular dementia: the three-city study. Diabetes Care 32(1):169–174CrossRefGoogle Scholar
  38. Reemtsma JP (1996) Im Keller. Hamburg Edition HIS Verlagsgesellschaft, HamburgGoogle Scholar
  39. Reitz C, Brayne C, Mayeux R (2011) Epidemiology of Alzheimer disease. Nat Rev Neurol 7(3):137–152CrossRefGoogle Scholar
  40. Richter K, Peter L, Lehfeld H, Zaske H, Brar-Reissinger S, Niklewski G (2018) Prevalence of psychiatric diagnoses in asylum seekers with follow-up. BMC Psychiatry 18(1):206CrossRefGoogle Scholar
  41. Roberts NP, Roberts PA, Jones N, Bisson JI (2016) Psychological therapies for post-traumatic stress disorder and comorbid substance use disorder. Cochrane Database Syst Rev 4:CD010204Google Scholar
  42. Rogers J, Watt I, Dieppe P (1981) Arthritis in Saxon and mediaeval skeletons. Br Med J (Clin Res Ed) 283(6307):1668–1670CrossRefGoogle Scholar
  43. Rolland-Cachera MF, Deheeger M, Maillot M, Bellisle F (2006) Early adiposity rebound: causes and consequences for obesity in children and adults. Int J Obes (Lond) 30(Suppl 4):S11–S17CrossRefGoogle Scholar
  44. Rosenbaum S, Stubbs B, Ward PB, Steel Z, Lederman O, Vancampfort D (2015) The prevalence and risk of metabolic syndrome and its components among people with posttraumatic stress disorder: a systematic review and meta-analysis. Metabolism. 64(8):926–933CrossRefGoogle Scholar
  45. Rothschild BM, Woods RJ (1990) Symmetrical erosive disease in Archaic Indians: the origin of rheumatoid arthritis in the new world? Semin Arthritis Rheum 19(5):278–284CrossRefGoogle Scholar
  46. Schellong K, Schulz S, Harder T, Plagemann A (2012) Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PLoS ONE 7(10):e47776CrossRefGoogle Scholar
  47. Schumacher M, Schulgen G (2008) Methodik klinischer Studien. Springer, BerlinGoogle Scholar
  48. Schwartz MW, Seeley RJ, Zeltser LM, Drewnowski A, Ravussin E, Redman LM et al (2017) Obesity pathogenesis: an endocrine society scientific statement. Endocr Rev 38(4):267–296CrossRefGoogle Scholar
  49. Scott RA, Scott LJ, Magi R, Marullo L, Gaulton KJ, Kaakinen M et al (2017) An expanded genome-wide association study of type 2 diabetes in Europeans. Diabetes 66(11):2888–2902CrossRefGoogle Scholar
  50. Short CL (1974) The antiquity of rheumatoid arthritis. Arthritis Rheum 17(3):193–205CrossRefGoogle Scholar
  51. Snyder EY, Kim SU (1980) Insulin: is it a nerve survival factor? Brain Res 196(2):565–571CrossRefGoogle Scholar
  52. Spalding KL, Arner E, Westermark PO, Bernard S, Buchholz BA, Bergmann O et al (2008) Dynamics of fat cell turnover in humans. Nature 453(7196):783–787CrossRefGoogle Scholar
  53. Straub RH (2018) Altern, Müdigkeit und Entzündungen verstehen – Wenn Immunsystem und Gehirn um die Energie im Körper ringen. Springer, BerlinCrossRefGoogle Scholar
  54. Straub RH (2007) The complex role of estrogens in inflammation. Endocr Rev 28(5):521–574CrossRefGoogle Scholar
  55. Sturrock RD, Sharma JN, Buchanan WW (1977) Evidence of rheumatoid arthritis in ancient India. Arthritis Rheum 20(1):42–44CrossRefGoogle Scholar
  56. Sydenham T (1848) Chapter V: Rheumatism. In: Greenhill WA, Latham RG (Hrsg) The works of Thomas Sydenham MD. 1 and 2. Sydenham Society, London, S 254–259Google Scholar
  57. Vainik U, Baker TE, Dadar M, Zeighami Y, Michaud A, Zhang Y et al (2018) Neurobehavioral correlates of obesity are largely heritable. Proc Natl Acad Sci U S A. 115(37):9312–9317CrossRefGoogle Scholar
  58. van der Kolk B (2014) The body keeps the score – mind, brain and body in transformation of trauma. Penguin Random House, New YorkGoogle Scholar
  59. van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND et al (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360(15):1500–1508CrossRefGoogle Scholar
  60. Vanhanen M, Koivisto K, Moilanen L, Helkala EL, Hanninen T, Soininen H et al (2006) Association of metabolic syndrome with Alzheimer disease: a population-based study. Neurology 67(5):843–847CrossRefGoogle Scholar
  61. Wu H, Liao W, Li Q, Long H, Yin H, Zhao M et al (2018) Pathogenic role of tissue-resident memory T cells in autoimmune diseases. Autoimmun Rev 17(9):906–911CrossRefGoogle Scholar
  62. Yoshida T, Mei H, Dorner T, Hiepe F, Radbruch A, Fillatreau S et al (2010) Memory B and memory plasma cells. Immunol Rev 237(1):117–139CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2020

Authors and Affiliations

  1. 1.Klinik für Innere MedizinUniversitätsklinikum RegensburgRegensburgDeutschland

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