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Genetics in Rotator Cuff Tears: First Steps to the Future

  • Carina Cohen
  • Eduardo A. Figueiredo
  • Mariana F. Leal
  • Benno Ejnisman
Chapter

Abstract

The etiology of rotator cuff disease is multifactorial with extrinsic and intrinsic tendon factors being proposed to explain it. But also, prior studies provide preliminary evidence for genetic and familial predisposition to rotator cuff tears. Genetics are probably the key to the future, although data is still scarce, in its very beginning, and poorly understood.

Identifying genetic differences associated with rotator cuff tears could help our understanding of the disease, early detection, and assistance to individuals at risk for development of nontraumatic tears and provide potential future gene therapies.

Keywords

Rotator cuff disease Tendon degeneration Pathogenesis Etiology Genetic Gene expression Polymorphisms 

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Copyright information

© ISAKOS 2019

Authors and Affiliations

  • Carina Cohen
    • 1
  • Eduardo A. Figueiredo
    • 1
  • Mariana F. Leal
    • 2
  • Benno Ejnisman
    • 1
  1. 1.Shoulder and Elbow Group of Sports Traumatology CenterFederal University of São PauloSão PauloBrazil
  2. 2.Morphology and Genetic DepartmentFederal University of São PauloSão PauloBrazil

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