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Biologic Augmentation in RC Repair (Patches and Grafts): Part II

  • Kristi Hultman
  • Brandon J. Erickson
  • Meghan E. Bishop
  • Anthony A. RomeoEmail author
Chapter

Abstract

Rotator cuff tears are common problems among middle age and older adults that can result in significant morbidity. While many patients do well after rotator cuff repair, there is still a high percentage of patients with recurrent tearing of their rotator cuff. There is great interest in the use of biologic augmentation of rotator cuff repairs to improve tendon healing and encourage a more native-like tendon-to-bone attachment after repair. In vitro studies have shown promise, with results demonstrating significant improvement in strength and collagen orientation with the use of platelet-rich plasma (PRP) and stem cells, as well as matrix metalloproteinases (MMP) modulating antibiotics. However, in vivo studies still struggle to show significant benefits in the biomechanical properties, patient functionality, or clinical outcomes. More research is needed to better understand these biologic factors to optimize healing results.

Keywords

Biologic augmentation Rotator cuff Outcomes Stem cells Platelet-rich plasma 

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Copyright information

© ISAKOS 2019

Authors and Affiliations

  • Kristi Hultman
    • 1
  • Brandon J. Erickson
    • 2
  • Meghan E. Bishop
    • 2
  • Anthony A. Romeo
    • 2
    Email author
  1. 1.Rothman InstitutePhiladelphiaUSA
  2. 2.Rothman InstituteNew YorkUSA

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