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Endometriose

  • Wolfgang KüpkerEmail author
  • Admir Agic
Chapter
Part of the Springer Reference Medizin book series (SRM)

Zusammenfassung

Endometriose, die wahrscheinlich häufigste benigne Erkrankung in der Frauenheilkunde, bedeutet für die betroffenen Frauen eine oftmals unerträgliche Zeit von etwa 8–10 Jahren bis zur Diagnosesicherung. Ein intensives Gespräch mit der Patientin, eine genaue gynäkologische Spiegel- und Tastuntersuchung und eine Transvaginalsonografie ermöglichen die Diagnose. Die Diagnose bedarf der Absicherung. Hier kann die MRT-Technologie einen wichtigen Beitrag liefern. Einen spezifischen Marker aus Blut oder Serum gibt es bis dato nicht – trotz intensiver Beforschung einer solchen sicherlich eleganten Option. Ob es einen hinreichend beweiskräftigen Marker geben wird und ob ein solcher wirklich sinnvoll sein kann, bleibt abzuwarten. Bis dato gilt immer noch die operative Abklärung per laparoscopiam als Goldstandard.

Literatur

  1. Adamson GD, Pasta DJ (2010) Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril 94:1609–1615PubMedCrossRefGoogle Scholar
  2. Alborzi S, Momtahan M, Parsanezhad ME, Dehbashi S, Zolghadri J, Alborzi S (2004) A prospective, randomized study comparing laparoscopic ovarian cystectomy versus fenestration and coagulation in patients with endometriomas. Fertil Steril 82:1633–1637PubMedCrossRefGoogle Scholar
  3. ASRM classification of endometriosis (1996) Fertil Steril 67:817–821Google Scholar
  4. Balasch J, Creus M, Fabregues F et al (1996) Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study. Hum Reprod 11:387–391PubMedCrossRefGoogle Scholar
  5. Ballester M, Roman H, Mathieu E, Touleimat S, Belghiti J, Darai E (2017) Prior colorectal surgery for endometriosis-associated infertility improves ICSI-IVF outcomes: results from expert centres. Eur J Obstet Gynecol Reprod Biol 209:95–99PubMedCrossRefGoogle Scholar
  6. Benschop L, Farquhar C, van der Poel N, Heineman MJ (2010) Interventions for women with endometrioma prior to assisted reproductive technology. Cochrane Database Syst Rev (11):CD008571Google Scholar
  7. Bianchi PHM, Pereira RMA, Zanatta A, Alegretti JR, Motta ELA, Serafini PC (2009) Extensive excision of deep infiltrative endometriosis before in vitro fertilization significantly improves pregnancy rates. J Minim Invasive Gynecol 16:174–180PubMedCrossRefGoogle Scholar
  8. Brinton LA, Gridley G, Persson I et al (1997) Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol 176:572–579. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15200778&query_hl=16&itool=pubmed_DocSum. Zugegriffen am 06.09.2019
  9. Brosens I, Puttemans P, Campo R et al (2004) Diagnosis of endometriosis: pelvic endoscopy and imaging techniques. Best Pract Res Clin Obstet Gynaecol 18:285–303PubMedCrossRefGoogle Scholar
  10. Buchweitz O, Staebler A, Tio J et al (2006) Detection of peritoneal endometriotic lesions by autofluorescence laparoscopy. Am J Obstet Gynecol 195:949–954PubMedCrossRefGoogle Scholar
  11. Daraï E, Lesieur B, Dubernard G, Rouzier R, Bazot M, Ballester M (2011) Fertility after colorectal resection for endometriosis: results of a prospective study comparing laparoscopy with open surgery. Fertil Steril 95:1903–1908PubMedCrossRefGoogle Scholar
  12. Darwish B, Roman H (2016) Surgical treatment of deep infiltrating rectal endometriosis: in favor of less aggressive surgery. Am J Obstet Gynecol 215(2):195–200PubMedCrossRefGoogle Scholar
  13. Demco L (2004) Laparoscopic spectral analysis of endometriosis. J Am Assoc Gynecol Laparosc 11:219–222PubMedCrossRefGoogle Scholar
  14. D’Hooghe TM (2003) Invisible microscopic endometriosis: how wrong is the sampson hypothesis of retrograde menstruation to explain the pathogenesis of endometriosis? Gynecol Obstet Investig 55:61–62CrossRefGoogle Scholar
  15. Dinulescu DM, Ince TA, Quade BJ et al (2005) Role of K-Ras and Pten in the development of mouse models of endometriosis and endometriod ovarian cancer. Nat Med 11:63–70PubMedCrossRefGoogle Scholar
  16. Donnez J, Nisolle M, Gillet N, Smets M, Bassil S, Casanas-Roux F (1996) Large ovarian endometriomas. Hum Reprod 11:641–646PubMedPubMedCentralCrossRefGoogle Scholar
  17. Douay-Hauser N, Yazbeck C, Walker F, Luton D, Madelenat P, Koskas M (2011) Infertile women with deep and intraperitoneal endometriosis: comparison of fertility outcome according to the extent of surgery. J Minim Invasive Gynecol 18:622–628PubMedCrossRefGoogle Scholar
  18. Dunselman GA, Vermeulen N, Becker C, Calhaz-Jorge C, D’hooghe T, De Bie B, Heikinheimo O, Horne AW, Kiesel L, Nap A, Prentice A, Saridogan E, Soriano D, Nelen W, European Society of Human Reproduction and Embryology (2014) ESHRE guideline: management of women with endometriosis. Hum Reprod 29(3):400–412.  https://doi.org/10.1093/humrep/det457. Epub 2014 Jan 15CrossRefPubMedPubMedCentralGoogle Scholar
  19. Evers JL, Dunselman GA, Groothuis P (2005) Now you see them, now you don’t. Fertil Steril 84:31–32; discussion 38–9. ReviewPubMedCrossRefPubMedCentralGoogle Scholar
  20. Hart RJ, Hickey M, Maouris P, Buckett W (2008) Excisional surgery versus ablative surgery for ovarian endometriomata. Cochrane Database Syst Rev (2):CD004992.  https://doi.org/10.1002/14651858
  21. Hillemanns P, Weingandt H, Stepp H et al (2000) Assessment of 5-aminolevulinic acid-induced porphyrin fluorescence in patients with peritoneal endometriosis. Am J Obstet Gynecol 183:52–57PubMedGoogle Scholar
  22. Huffman JW (1981) Endometriosis in young teen-age girls. Pediatr Ann 10:44–49PubMedGoogle Scholar
  23. Jacobson TZ, Duffy JMN, Barlow D, Farquhar C, Koninckx PR, Olive D (2010) Laparoscopic surgery for subfertility associated with endometriosis. Editorial Group: Cochrane Menstrual Disorders and Subfertility Group. Cochrane Database Syst Rev (1):CD001398.  https://doi.org/10.1002/14651858.CD001398.pub2
  24. Kang SB, Chung HH, Lee HP et al (2006) Impact of diagnostic laparoscopy on the management of chronic pelvic pain. Surg Endosc 14: 916–919PubMedCrossRefGoogle Scholar
  25. Kohl Schwartz AS, Wölfler MM, Mitter V, Rauchfuss M, Haeberlin F, Eberhard M, von Orelli S, Imthurn B, Imesch P, Fink D, Leeners B (2017) Endometriosis, especially mild disease: a risk factor for miscarriages. Fertil Steril 108(5):806–814.e2.  https://doi.org/10.1016/j.fertnstert.2017.08.025CrossRefPubMedGoogle Scholar
  26. Kupker W, van der Linde H, Loning M et al (2004) Laparoscopic autofluorescence imaging of endometriosis. Fertil Steril 82:S72–S73CrossRefGoogle Scholar
  27. Kyama CM, Debrock S, Mwenda JM et al (2003) Potential involvement of the immune system in the development of endometriosis. Reprod Biol Endocrinol 1:121CrossRefGoogle Scholar
  28. Malik E, Berg C, Meyhofer-Malik A et al (2000) Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid. Surg Endosc 14:452–455PubMedCrossRefGoogle Scholar
  29. Marcoux S, Maheux R, Bérubé S (1997) Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis. N Engl J Med 337:217–222PubMedCrossRefGoogle Scholar
  30. Matalliotakis I, Mahutte NG, Koukoura O, Arici A (2006) Endometriosis-associated stage IA clear cell ovarian carcinoma in a woman with IVF-ET treatments in the Yale series. Arch Gynecol Obstet 274:184–186PubMedCrossRefGoogle Scholar
  31. Medina MG, Lebovic DI (2009) Endometriosis – associated nerve fibers and pain. Acta Obstet Gynecol Scand 88:968–975PubMedPubMedCentralCrossRefGoogle Scholar
  32. Melin A, Sparen P, Persson I (2006) Endometriosis and the risk of cancer with special emphasis on ovarian cancer. Hum Reprod 21:1237–1242PubMedCrossRefGoogle Scholar
  33. Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ (2004) Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol 160(8):784–796PubMedCrossRefGoogle Scholar
  34. Moini A, Riazi K, Amid V, Ashrafi M, Tehraninejad E, Madani T, Owj M (2005) Endometriosis may contribute to oocyte retrieval-induced pelvic inflammatory disease: report of eight cases. J Assist Reprod Genet 22:307–309PubMedCrossRefGoogle Scholar
  35. Murphy AA, Green WR, Bobbie D et al (1986) Unsuspected endometriosis documented by scanning electronmicroscopy in visualy normal peritoneum. Fertil Steril 46:522–524PubMedCrossRefGoogle Scholar
  36. Nezhat C, Crowgey S, Nezhat F (1989) Videolaseroscopy for the treatment of endometriosis associated with infertility. Fertil Steril 51:237–240PubMedCrossRefGoogle Scholar
  37. Opøien HK, Fedorcsak P, Byholm T, Tanbo T (2011) Complete surgical removal of minimal and mildendometriosis improves outcome of subsequent IVF/ICSI treatment. Reprod Biomed Online 23:389–395PubMedCrossRefGoogle Scholar
  38. Pagidas K, Falcone T, Hemmings R, Miron P (1996) Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer. Fertil Steril 65:791–795PubMedCrossRefGoogle Scholar
  39. Parazzini F (1999) Ablation of lesions or no treatment in minimal-mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell’Endometriosi. Hum Reprod 14:1332–1334PubMedCrossRefGoogle Scholar
  40. Peirce CL, Templeman C, Rossing MA (2012) On behalf of the Ovarian cancer Association Consortium. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol 13:385–394CrossRefGoogle Scholar
  41. Pellicer A, Albert C, Garrido N et al (2000) The pathophysiology of endometriosis – associated infertility: follicular environment and embryo quality. J Reprod Fertil Suppl 55:109–119PubMedGoogle Scholar
  42. Redwine DB (1999) Ovarian endometriosis: a marker for more extensive pelvic and intestinal disease. Fertil Steril 72:310–315PubMedCrossRefGoogle Scholar
  43. Rickes D, Nickel I, Kropf S, Kleinstein J (2002) Increased pregnancy rates after ultralong postoperative therapy with gonadotropin-releasing hormone analogs in patients with endometriosis. Fertil Steril 78:757–762PubMedCrossRefGoogle Scholar
  44. Sallam H, Garcia-Velasco J, Dias S, Arici A (2006) Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis. Cochrane Database Syst Rev (1):CD004635Google Scholar
  45. Sampson JA (1925) Endometrial carcinoma of ovary arisingin endometrial tissue in that organ. Arch Surg 10:1–72CrossRefGoogle Scholar
  46. Sinaii N, Ceary SD, Ballweg ML (2002) High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis. Hum Reprod 17:2715–2724PubMedCrossRefGoogle Scholar
  47. Stepniewska A, Pomini P, Bruni F, Mereu L, Ruffo G, Ceccaroni M, Scioscia M, Guerriero M, Minelli L (2009) Laparoscopic treatment of bowel endometriosis in infertile women. Hum Reprod 24:1619–1625PubMedCrossRefGoogle Scholar
  48. Tsoumpou I, Kyrgiou M, Gelbaya TA, Nardo LG (2009) The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis. Fertil Steril 92:75–87PubMedCrossRefGoogle Scholar
  49. Tuttlies F, Keckstein J, Ulrich U et al (2005) ENZIAN score: a classification of deep infiltrating endometriosis. Zentralbl Gynakol 127:275–281PubMedCrossRefGoogle Scholar
  50. Vercellini P, Fedele L, Aimi G, De Giorgi O, Consonni D, Crosignani PG (2006) Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system. Hum Reprod 21:2679–2685PubMedCrossRefGoogle Scholar
  51. Wolfram F, Riedlinger J, Weichbrodt M et al (2010) Sentinel lymph node labeling of patients with deep infiltrating rectovaginal endometriosis – does this make sense? J Endometr 2:33–40CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2020

Authors and Affiliations

  1. 1.Zentrum für Minimal Invasive Gynäkologie, Endometriose und ReproduktionsmedizinKlinikum MittelbadenBühlDeutschland
  2. 2.Klinik für Frauenheilkunde und GeburtshilfeKrankenhaus MühlackerMühlackerDeutschland

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