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Akne und Rosazea

  • Bodo Melnik
  • Wenchieh Chen
Chapter
Part of the Springer Reference Medizin book series (SRM)

Zusammenfassung

Akne und Rosazea zählen zu den häufigsten entzündlichen Hauterkrankungen, die eine konsequente Behandlung erfordern. Aktuelle pathogenetische Erkenntnisse erklären neue präventive und innovative Therapienansätze. Bei Acne vulgaris wurden Ernährungsfaktoren als wichtige Auslöser gesichert wie vermehrter Konsum von Milch und Kohlenhydraten, die den mTORC1-Signalweg und damit die Talgproduktion steigern. Endoplasmatischer Retikulum-Stress erklärt die klinischen Triggerfaktoren der Rosazea und erlaubt ein neues Verständnis der Rosazea. Die Acne inversa ist keine Akne im eigentlichen Sinn, sondern ist eine Entzündung terminaler Haarfollikel (dissecting terminal hair folliculitis). Primär besteht eine erhöhte Fragilität des Akroinfundibulums infolge verminderter Notch-Signale sowie eine Verbindung zu autoinflammatorischen Prozessen. Die Kenntnis dieser neuen Zusammenhänge ermöglicht moderne und zielgerichtete Therapien dieser häufigen, psychosozial oft stark belastenden Hautkrankheiten.

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Akne

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Rosazea

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Copyright information

© Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature 2018

Authors and Affiliations

  1. 1.Abteilung Dermatologie, Umweltmedizin und GesundheitstheorieUniversität OsnabrückOsnabrückDeutschland
  2. 2.HautarztpraxisGüterslohDeutschland
  3. 3.Klinik und Poliklinik für Dermatologie und Allergologie am BiedersteinTechnische Universität MünchenMünchenDeutschland

Section editors and affiliations

  • Thomas Ruzicka
    • 1
  1. 1.Klinik und Poliklinik für Dermatologie und AllergologieUniversität MünchenMünchenDeutschland

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