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Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspectives

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Surgery of the Meniscus

Abstract

Meniscal tears are common, prevalent intra-articular knee injury and the most frequent cause of orthopedic surgical procedures [1], being a significant risk factor for the development of osteoarthritis (OA) [2]. As widely documented in the previous chapters, tears in the peripheral (vascularized) portion of the meniscus can be repaired using a variety of operative procedures, while those in the central (avascular) area have a poorer healing capacity. Reconstruction of a torn meniscus in this location is challenging, and the long-term effect of allografts on the progression of OA remains uncertain [3].

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Acknowledgment

Parts of this chapter have been published by Angele et al., JEO1 (2014).

Author information

Authors and Affiliations

  1. II Clinic – Biomechanics and Innovation Technology Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy

    Stefano Zaffagnini & Giuseppe Filardo

  2. Center of Experimental Orthopaedics, Saarland University Medical Center, Homburg/Saar, Germany

    Magali Cucchiarini & Henning Madry

  3. Orthopaedic Biotechnology Laboratory, IRCCS Galeazzi Orthopaedic Institute, Milan, Italy

    Laura de Girolamo & Carlotta Perucca Orfei

  4. Department of Trauma Surgery, University Medical Center Regensburg, Regensburg, Germany

    Peter Angele & Johannes Zellner

  5. Sporthopaedicum, Regensburg, Germany

    Peter Angele

  6. Orthopedic Department, Centro Hospitalar Póvoa de Varzim - Vila do Conde, Vila do Conde, Portugal

    Helder Pereira

  7. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Univ. Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Guimarães, Portugal

    Helder Pereira

  8. ICVS/3B’s – PT Government Associated Laboratory, Braga, Portugal

    Helder Pereira & Rui L. Reis

  9. Ripoll y De Prado Sports Clinic FIFA Medical Centre of Excellence, Murcia-Madrid, Spain

    Helder Pereira

  10. Tissue Engineering and Regenerative Medicine, 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal

    Rui L. Reis

  11. Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg/Saar, Germany

    Henning Madry

Authors
  1. Stefano Zaffagnini
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  2. Magali Cucchiarini
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  3. Laura de Girolamo
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  4. Peter Angele
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  5. Helder Pereira
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  6. Rui L. Reis
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  7. Henning Madry
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  8. Carlotta Perucca Orfei
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  9. Johannes Zellner
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  10. Giuseppe Filardo
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Corresponding author

Correspondence to Stefano Zaffagnini .

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Editors and Affiliations

  1. Orthopaedics & Traumatology, Unit INSERM, Normandy University, Caen university Hos, Caen, France

    Christophe Hulet

  2. Orthopedic Department, Centro Hospitalar Póvoa de Varzim –Vila, Póvoa de Varzim, Porto, Portugal

    Helder Pereira

  3. University of Milan, Dpt. of Biomedical Sciences for Health, Milano, Italy

    Giuseppe Peretti

  4. Istituto Clinico Humanitas, Monza, Italy

    Matteo Denti

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Zaffagnini, S. et al. (2016). Gene Therapy, Growth Factors, Mesenchymal Cells, New Trends and Future Perspectives. In: Hulet, C., Pereira, H., Peretti, G., Denti, M. (eds) Surgery of the Meniscus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-49188-1_58

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