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Modellstudien über virusbedingte Tumoren und deren immunologische Behandlung

  • W. Schäfer
Chapter
Part of the Verhandlungen der Gesellschaft Deutscher Naturforscher und Ärzte book series (NATURFORSCHER, volume 109. 1976)

Zusammenfassung

Nach einer Übersicht über das allgemeine Verhalten der C-Typ-Onkorna-Viren werden die Ergebnisse eigener Untersuchungen über die Struktur eines exogenen Mäuse-Leukämie-Virus (FLV) und über die serobiologischen Eigenschaften seiner Strukturproteine geschildert. Die dabei gewonnenen Erkenntnisse ließen vermuten, daß das an der Virusoberfläche gelegene Glykoprotein gp71 eine wichtige Rolle bei der Immunabwehr spielt. Vakzinie-rungsversuche mit isoliertem Glykoprotein bei Mäusen bestätigten diese Vermutung. Sie zeigten aber auch, daß die entsprechende Immunantwort der Maus eine hohe Spezifität besitzt und sich nicht auf endogene C-Viren, die anderen Serotypen angehören, erstreckt; diese wurden vielmehr durch Impfung mit FLV gp71 aktiviert.

In anderen Tierarten veranlaßte dagegen isoliertes FLV gp71 die Bildung von breit reagierenden Antikörpern. Diese waren nicht nur bei FLV-infizierten Mäusen, sondern auch bei Infektionen von Katzen mit einem Katzen-Leukämie-Virus serotherapeutisch wirksam. Besonders eindrucksvolle Erfolge wurden bei der Behandlung von Virus-induzierten Sarkomen der Katze mit einem Antiserum erzielt, das gegen Katzen-Leukämie-Virus in einer Ziege hergestellt wurde.

Schlüsselwörter

Säuger C-Typ Onkorna-Viren Struktur Virus-Komponenten Immunoprophylaxe Immunotherapie. 

Summary

After a review of the general biological properties of C-type oncorna viruses, results are presented on the structure of an exogenous murine leukemia virus (FLV) and on the serobiological properties of its structural proteins. Our findings suggested a major role of the viral surface glycoprotein gp71 in immunological defense mechanisms. This was confirmed by vaccination experiments with isolated gp71 in mice. The induced immunity was highly specific and not operative against endogenous murine C-viruses belonging to other serotypes. Surprisingly the latter were found to be activated by the vaccination with gp71 of FLV.

In heterologous animal species isolated FLV-gp71 induced the formation of broadly reacting antibodies. They were found to be effective in the therapy of infections with FLV in mice as well as with feline leukaemia virus in cats. Most impressive results were obtained with an antiserum prepared against feline leukaemia virus in a goat. This serum completely suppressed sarcomas induced by infection with feline sarcoma virus.

Key words

Mammalian C-type oncorna viruses Structure Viral components Immunoprophylaxis Immunotherapy. 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1978

Authors and Affiliations

  • W. Schäfer
    • 1
  1. 1.Max-Planck-Institut für VirusforschungTübingenBundesrepublik Deutschland

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