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Virustropismus. Neue Erkenntnisse aus Untersuchungen über die Enterovirus-Infektion der Zelle

  • Leroy C. McLaren
  • Gerhard Brand
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 38)

Zusammenfassung

Die vorliegende Übersicht stellt sich zur Aufgabe, einige neuere Forschungsergebnisse über die biologischen Ursachen des Virustropismus zu diskutieren, wie sie insbesondere bei Untersuchungen über den Infektionsmechanismus der Enteroviren erzielt wurden. Diese Virusgruppe ist während der letzten Jahre im Zuge der massiven Attacke gegen die Poliomyelitis intensiv studiert worden, vor allem das Poliovirus selbst, dann aber auch die Coxsackie- und die ECHO-Viren. Wieweit die an Enteroviren erworbenen Kenntnisse auf andere Gruppen der menschund tierpathogenen Virusarten (Lwoff, Horne und Tournier 1963) übertragen werden dürfen, muß dahingestellt bleiben. Trotz zahlreicher gemeinsamer Eigenschaften der Virusarten bestehen im einzelnen erhebliche biologische Unterschiede zwischen Enteroviren, Myxoviren, Poxviren, Adenoviren, Reoviren, Herpesviren, Arborviren, um nur die für den Arzt und den medizinischen Wissenschaftler wichtigsten Gruppen zu nennen. Jedenfalls sind unsere Kenntnisse über die Infektionsmechanismen dieser verschiedenen Virusarten alles andere als vollständig, namentlich wenn man das Geschehen auf der cellulären oder makromolekularen Ebene ins Auge faßt.

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  • Leroy C. McLaren
  • Gerhard Brand

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