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Enzyme pp 481-498 | Cite as

Thiaminpyrophosphat enthaltende Enzyme

  • Friedrich H. Bruns
Chapter
Part of the Handbuch der Physiologisch- und Pathologisch-Chemischen Analyse book series (HOPPE-SEYLER)

Zusammenfassung

Auhagen1 konnte im Jahre 1932 zeigen, daß die von Neuberg und Karczag2 entdeckte anaerobe Pyruvat-Decarboxylase ihre Aktivität in Trockenhefe während des Waschens mit alkalischer Phosphatlösung verliert und daß diese sich durch Zugabe der Waschflüssigkeit wiederherstellen läßt. In der Folge fand Simola3 Vitamin BiAktivität in den Cocarboxylase-Präparaten Auhagens. Die Aufklärung der chemischen Natur des Coenzyms gelang Lohmann und Schuster4, indem sie aus Hefe den Pyrophosphatester des Aneurins (Thiaminpyrophosphat = TPP, Aneurinpyrophosphat, Diphosphothiamin) isolierten und nachweisen konnten, daß er als Coenzym der Pyruvat-Decarboxylierung wirksam ist.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1967

Authors and Affiliations

  • Friedrich H. Bruns
    • 1
  1. 1.Institut für Physiologische ChemieUniversität DüsseldorfDeutschland

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