Monitoring And Prediction Of Nervous Functions In Space

  • W. Ross Adey
  • Don D. Flickinger


Initial results obtained from monitoring human performance, during manned orbital flight of 9 hours duration (U. S.) and 96 hours duration (USSR) indicate little, if any, demonstrable degradation from these levels achieved during ground-based simulator runs. With available biomedical instrumentation in current use, however, no critical assessment of central nervous system function has been possible during the U. S. missions. Recognizing the extreme importance of monitoring and evaluating alertness, judgment, purposeful motor responsiveness during critical stages of future space missions, we have developed prototype EEG recording equipment which meets the unique and rigid requirements imposed during space flight.

Concomitantly with the required equipment and test and development there have been conducted a series of studies in animals exposed to simulated stresses of space flight up to 14 days duration. These studies have included the effects of acceleration, vibration, sensory deprivation, hallucinogenic drugs on discriminative performance, alertness and sleep-wakefulness cycles; with concomitant assays being made of steroid and catechol amine metabolism.

As a basic keystone around which our final objective could be realized, the UCLA Space Biology Laboratory has pioneered in the application of 3 complex computer techniques to the analysis of the EEG data recorded. Differences in these various quantitative and qualitative functions analyzed have been seen in many of the responses studied and the results thus far encourage the view that these techniques are more revealing of early significant changes than most others in current use.


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  1. 1.
    W. R. Adey, Use of Correlation Analysis in EEG Studies of Conditioning. In: Symposium, Editor M. A. B. Brazier, “Computer Techniques in EEG Analysis.” Electroenceph. Clin. Neurophysiol., Suppl. 20, 41 (1961).Google Scholar
  2. 2.
    W. R. Adey, F. R. Bell, and B. J. Dennis, Effects of LSD, Psilocybin and Psilocin on Temporal Lobe EEG Patterns and Learned Behavior in the Cat. Neurology 12, 591 (1962).CrossRefGoogle Scholar
  3. 3.
    W. R. Adey, C. W. Dunlop, and C. E. Hendrix, Hippocampal Slow Waves; Distribution and Phase Relations in the Course of Approach Learning. Amer. Med. Ass. Arch. Neurol. 3, 74 (1960).CrossRefGoogle Scholar
  4. 4.
    W. R. Adey, J. D. French, R. T. Kado, D. F. Lindslay, D. O. Walter, R. Wendt, and W. D. Winters, EEG Records from Cortical and Deep Brain Structures During Centrifugal and Vibrational Accelerations in Cats and Monkeys. Inst. Radio Eng. Trans. Biomed. Electronics, В ME-8, 182 (1961).Google Scholar
  5. 5.
    W. R. Adey and D. O. Walter, Application of Phase Detection and Averaging Techniques in Computer Analysis of EEG Records in the Cat. In press.Google Scholar
  6. 6.
    W. R. Adey, D. O. Walter, and C. E. Hendrix, Computer Techniques in Correlation and Spectral Analysis of Cerebral Slow Waves During Monitoring and Prediction of Nervous Functions in Space Discriminative Behavior. Exper. Neurol. 3, 501 (1961).CrossRefGoogle Scholar
  7. 7. W. R. Adey, W. D. Winters, R. T. Kado, and M. R. DeLucchi, EEG in Simulated Stresses of Space Flight with Special Reference to Problems of Vibration. Electroenceph. Clin. Neurophysiol., in press.Google Scholar
  8. 8.
    M. Baldwin, S. A. Lewis, and S. A. Bach, The Effects of Lysergic Acid After Cerebral Ablation. Neurology 9, 469 (1959).CrossRefGoogle Scholar
  9. 9.
    R. B. Blackman and J. W. Tukey, The Measurement of Power Spectra. New York: Dover Publications, 1959.zbMATHGoogle Scholar
  10. 10.
    N. R. Goodman, Measuring Amplitude and Phase. J. Franklin Inst. 270, 437 (I960).CrossRefGoogle Scholar
  11. 11.
    A. Graybiel, F. E. Guedry, W. H. Johnson, and R. S. Kennedy, Adap¬tation to Bizarre Stimulation of the Semicircular Canals as Indicated by the Oculogyral Illusion. Aerospace Med. 32, 321 (1961).Google Scholar
  12. 12.
    M. Jouvet, Research on the Neurophysiological Mechanisms of Sleep and Attention. Technical Final Report, U.S. Air Force of Scientific Research, ARDC, 48 pp., 1961.Google Scholar
  13. 13.
    R.T. Kado and W.R. Adey, A Transistorized Preamplifier for Field Study of EEG, Proc. 4th Internat. Conference on Med. Electronics, 1961, p. 172.Google Scholar
  14. 14.
    D. F. Lindsley, R. H. Wendt, R. Fugett, D.B. Lindsley, and W. R. Adey, Diurnal Activity Cycles in Monkeys under Prolonged Visual-pattern Deprivation. J.Compl. Physiol. Psychol. 55, 633 (1962).CrossRefGoogle Scholar
  15. 15.
    R. D. Middlebrook and A. T. Taylor, Differential Amplifier with Regulator Achieves High Stability, Low Drift. Electronics 34, 56 (1961).Google Scholar
  16. 16.
    L. Molnar, Effet de la stimulation du labyrinthe sur l’ activite electrique normale et pathologique de llecorce cerebrale du chat et de l’homme. Actualites Neurophysiol. 3, 61 (1961).Google Scholar
  17. 17.
    C. W. Sem. Jacobsen, Electroencephalographic Studies of Pilot Stresses in Flight. Aerospace Med. 30, 797 (1959).Google Scholar
  18. 18.
    D. G. Simons and N. R. Burch, EEG Telemetry and Automatic Analysis under Simulated Flight Conditions: a Comparative Study of Analytic Techniques. Amer. Electroencephalographic Society, Proc. 16th Annual Meeting, Atlantic City, 1962.Google Scholar
  19. 19.
    D. O. Walter, P. H. CrandaU, R. W. Rand, C.H. Markham, W.R. Adey, L. F. Chapman, and M. A. B. Brazier, The Use of Depth Electrode Studies as an Aid for the Surgical Selection of Patients with Bilateral Temporal Foci. Proc. American Electroencephalo¬graphic Society, 16th Annual Meeting, 1962, pp. 21-22.Google Scholar
  20. 20.
    W.D.Winters, The Effects of Confinement, Centrifugation and Vibration on the Urinary Excretion of 17-ketosteroids, 17-ketogenic Steroids, Catechol Amines and Urinary Output in the Monkey. In press.Google Scholar
  21. 21.
    W. D. Winters, R. T. Kado and W. R. Adey, Neurophysiological Aspects of Space Flight. Proceedings of Symposium, “Manned Lunar Flightff, American Astronautical Society, Denver, December, 1961. Vol. 10, pp. 181–209, 1963.Google Scholar

Copyright information

© Springer-Verlag Wien 1965

Authors and Affiliations

  • W. Ross Adey
    • 1
  • Don D. Flickinger
    • 2
  1. 1.Space Biology Laboratory, Brain Research InstituteUniversity of CaliforniaLos AngelesUSA
  2. 2.Life SciencesUSA

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