Inhibition of Drug Metabolism by small Concentrations of Carbon Disulfide / Hemmung des Arzneimittelstoffwechsels durch geringe Schwefelkohlen-Stoffkonzentrationen

  • Klaus J. Freundt
  • W. Dreher


Carbon disulfide inhibits the activity of various enzymes in serum and in tissue both in vivo and in vitro [1,3–7]. We have examined the effect of small concentrations of CS2 on the metabolism of various drugs by the liver, since there has been a suggestion of interference [2]. We used hexobarbital-Na, aminophenazone, and procaine-HCl.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • Klaus J. Freundt
    • 1
  • W. Dreher
  1. 1.Institut f. Toxikologie u. Pharmakologie der UniversitätWürzburgDeutschland

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