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Zum Wirkungsmechanismus der Herzglykoside / The Mechanism of Action of Cardiac Glycosides

  • H. J. Schatzmann
Chapter

Zusammenfassung

Seit 1785, dem Erscheinungsjahr von Witherings „An Account of the Foxglove and Some of its Medical Uses“ kennt die medizinische Welt die richtige Indikation und die richtige Dosierung einer herzglykosidführenden Droge, des Blatts der Digitalis. 183 Jahre lang hat die klinische Medizin diese Grundsätze überprüft verfeinert, auf andere Drogen und Reinglykoside übertragen. Es ist unwahrscheinlich, daß die Ärzte Grund hätten, ihre Verfahren zur Behandlung der Herzinsuffizienz zu ändern, wenn der Wirkungsmechanismus der Herzglykoside bekannt würde. Es ist deshalb klar, daß die Suche nach dem Wirkungsmechanismus dieser Stoffklasse nicht durch ein dringendes Bedürfnis der Praxis zu rechtfertigen ist. Der Grund für das nicht abflauende Interesse, das die Pharmakologie dieser Stoffe findet, liegt wohl in der Tatsache, daß man beim Studium der Herzglykosidwirkung recht weit in den molekularen Bereich vorgedrungen ist und häufig neue Erkenntnisse der Physiologie in die Überlegungen einbeziehen muß. Trotz der regen Tätigkeit scheint man immer noch weit davon entfernt zu sein, eine endgültige Erklärung für die positiv inotrope Wirkung dieser Verbindungen geben zu können.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1969

Authors and Affiliations

  • H. J. Schatzmann
    • 1
  1. 1.Veterinär-pharmakologisches Institut der UniversitätBernSchweiz

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